摘要
以黄嘌呤氧化酶／次黄嘌呤自由基诱生系统建立了稳定的离体心肌线粒体的损伤模型，并应用此模型研究了辣根过氧化物酶对心肌线粒体自由基氧化损伤的保护作用．结果表明，辣根过氧化物酶能抑制心肌线粒体中氧自由基的形成，降低膜脂的过氧化水平，保护了线粒体膜酶活性，有效地防止了自由基对线粒体结构和功能的损伤．
The protection of myocardial mitochondria against the free radical injury byhorseradish peroxidase was studied. The free radical injury model of mitochondria in vitrowas set up. Horseradish peroxidase could inhibit the generation of free radicals and lipidperoxides, keep cytochrome oxidase of mitochondria membrane with a high activity, and makethe mitochondria remain relative intact in structure. The results suggest that horseradishperoxidase as peroxide scarvenger could decrease the free radical injury of mitochondria.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第10期1628-1632,共5页
Chemical Journal of Chinese Universities
基金
高等学校博士学科点专项科研基金!06040501
