摘要
棘球蚴可以依赖有效的免疫逃避机制在宿主体内长期生存,并造成慢性感染。包囊囊壁、原头节和囊液等所含抗原物质多而复杂,在逃避宿主的免疫应答中起重要作用。棘球蚴逃避宿主免疫反应机制分为主动免疫逃避与免疫调节两种:棘球蚴通过抑制补体的激活,耗竭特异性抗体,影响T细胞活性,下调B细胞功能等有效地避开宿主的免疫反应。棘球蚴的EgTeg蛋白和囊液中的抗原B等能明显抑制中性粒细胞的趋化作用;刺激宿主产生TH2型细胞因子,激发非保护性的免疫应答;干扰单核细胞分化和调节树突状细胞的表型,逃逸宿主免疫监视。
Echinococcus can live in the host for a long time because of an effective escape from immune response of host, and cause chronic infection. Cyst,protoscotex and the cystic fluid of Echinococcus contain a lot of different antigenic materials, which play an important role in immune escape. There are two types in immune escape mechanisms,including active immunity and immunological regulation. Echinococcus cyst can effectively avoid the host immune response by inhib- iting the activation of complement, depleting of specific antibodies, affecting T cell activity and lowering B-cell function. The protein EgTeg of hydatid cyst and antigen B in hydatid fluid can significantly inhibit the neutrophil chemotaxis, stimu- late host to produce cytokines TH2, which means stimulating the non-protective immune response, and interference in monoeyte differentiation and regulation of phenotype of dendritic cells, resulting in escaping the host immune surveillance.
出处
《中国病原生物学杂志》
CSCD
2008年第10期788-791,共4页
Journal of Pathogen Biology
基金
国家自然科学基金资助项目(No.30560146)
国家教育部春晖项目(No.Z2004-2-65004)
关键词
细粒棘球蚴
免疫逃避
分子
综述
Echinococcosis
immune escape
molecule
review
