摘要
目的了解败血症患者血液中分离病原菌种类、耐药性及感染危险因素。方法血液培养利用BDBACTECMGIT9120仪,大多数细菌的鉴定和药敏试验利用BDPhoenix仪,少数利用手工鉴定和K-B法药敏试验。数据分析用WHONET5.4和Excel2003软件。结果败血症患者血液中分离病原菌常见属种为葡萄球菌属、埃希菌属、铜绿假单胞菌、克雷伯氏菌属、念珠菌属、链球菌属。G+球菌万古霉素的耐药率一直为0.0%。G-杆菌耐药率低于30%的抗生素为头孢哌酮/舒巴坦、亚胺培南、阿米卡星、左旋氧氟沙星和哌拉西林/他唑巴坦。败血症感染危险因素主要包括静脉插管、吸氧、穿刺(骨)、化疗、免疫抑制剂、WBC计数<1.5×109/L。结论临床医生应重视对疑为败血症患者进行血液培养,根据培养鉴定和药敏结果合理使用抗生素。
Objective To analyse distribution,drug resistance and risk factors of pathogens isolated from septicemia cases. Methods Blood specimens were cultured and detected with BACTECMGIT9120. Most bacterial isolates were identified by BD Phoenix, a few were identified by handy-method or K-B method. WHONET 5.4 and Excel 2003 were applied for analysis. Results The common isolates from septicemia cases were Staphylococcus, Escherichia, P. aeruginosa, Klebsiella, Candida, and Streptococcus. In gram positive isolates,resistant rate of vancomycin was 0.0%. In gram negative isolates, resistant rates of Cef-operazone/Sulbactam, Imipenem, Amikacin, Levofloxacin, and Piperacillin/Tazobactam were under 30%. Risk factors of septicemia were vein catheterization, oxygen therapy, centesis （ bone）, chemotherapy, immun blocking agent,WBC 〈1.5×10^9/L. Conclusions It is important to promote blood culture rate of septicemia and use antimicrobial agents refer to results of identification and resistant rates of pathogen isolated from blood.
出处
《临床内科杂志》
CAS
2008年第10期699-702,共4页
Journal of Clinical Internal Medicine
关键词
败血症
病原菌
耐药
危险因素
Septicemia
Pathogen
Drug resistance
Risk factor
