摘要
目的通过对代谢综合征患者心率变异性分析(HRV),探讨代谢综合征对心脏自主神经功能的影响及其临床意义。方法选择108例住院患者,分为对照组(60例)和代谢综合征组(48例)。并对代谢综合征组按体重指数(BMI)分为三个亚组:体重正常(BMI<23kg/2)、超重(BMI23～24.9kg/m2)、肥胖(BMI≥25kg/m2)。所有患者行24小时动态心电图(Holter)检查,采集HRV时域指标和频域指标。同时测定空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、C反应蛋白(CRP),计算胰岛素抵抗指数HOMA-IR。结果与对照组相比,代谢综合征组时域指标下降(P<0.05),频域指标亦下降(P<0.05);各亚组比较,随BMI升高,各时域指标、频域指标均下降(P<0.05);HOMA-IR、HbA1c、TC、TG、CRP均上升(P<0.05)。结论代谢综合征患者心率变异性下降,与肥胖、胰岛素抵抗有关。
Objective To observe the change of the heart rate variability （HRV）and research dysfunction of the autonomic nervous system in patients with metabolic syndrome （MS）. Methods 48 MS were compared with 60 control subjects. The changes in glycolipid metabolism as well as plasma C-reactive protein （CRP）, the HOMA insulin resistance index （HOMA-IR） and 24-hours ECG recording were ob- served. Results Frequency and time threshold of HRV in the MS group were significantly decreased rela- tive to the control group. With BMI increased,frequency and time threshold of HRV,HOMA-IR,HbA1c, TC,TG,CRP also increased. Conclusions HRV is decreased in MS patients ,might contribute to BMI and insulin resistance.
出处
《临床内科杂志》
CAS
2008年第10期687-689,共3页
Journal of Clinical Internal Medicine
关键词
代谢综合征
心率变异性
胰岛素抵抗
Metabolic syndrome
Heart rate variability
Insulin resistance
