摘要
目的探讨急性重症胆管炎(ACST)乳酸脱氢酶(LDH)、血小板(PLT)与凝血功能之间的关系。方法对急诊入院的42例ACST患者立刻采血,分别测定LDH、PLT、血浆纤维蛋白原(Fib)、血管性血友病因子(vWF)、纤维蛋白A肽(FPA)、血小板a颗粒膜蛋白-140(GMP-140)、抗凝血酶-Ⅲ(AT-Ⅲ)含量,并与正常对照组比较。结果与正常对照组比较,重症胆管炎患者LDH、vWF、GMP-140、FPA显著增高(P<0.05),PLT、AT-Ⅲ则显著降低(P<0.05),而Fib无显著差异(P>0.05)。结论重症胆管炎患者存在明显的组织损伤和凝血、抗凝血系统的功能紊乱,通过对ACST患者LDH、PLT及凝血功能的观察,可作为了解ACST病情严重程度和预后评估的客观指标。
Objective To observe the clinical significance of lactic dehydrogenase （LDH）, platelet and coagulation changes in acute severe cholangitis patients. Methods LDH , Platelet, fibrinogen （ Fib）, van Willebrand factor （vWF）, fibinopeptide A, platdet granulate membrane protein-140 （GMP-140） and antithrombin-Ⅲ （AT-Ⅲ） were measured in 42 consecutive patients suffering from acute severe cholangitis after emergency admission. Results All the patients showed an increase in LDH, GMP-140, vWF and FPA activity accompanied a significant decrease in PLT and AT-Ⅲ and there was no marked changes in Fib in patients with acute severe eholangitis. Conclusions There is a significant coagulation disorder in patients with acute severe cholangitis. Understand serious degree and post-assessment objective index through exploration for LDH, PLT and coagulation changes in patients suffered from ACST.
出处
《中国实用医药》
2008年第27期13-14,共2页
China Practical Medicine
关键词
急性重症胆管炎
乳酸脱氢酶
血小板
凝血
Acute severe cholangitis
Lactic dehydrogenase
Platelet
Coagulation
