摘要
应用流式细胞仪检测系统性红斑狼疮（SM）20例及正常人外周血新鲜分离的T淋巴细胞Fas抗原的表达；并采用ELISA法检测病人血浆中抗核抗体（ANA）的含量。结果发现，SLE病人外周血T淋巴细胞Fas的表达明显高于正常对照组（P＜0．01）；且活动期明显高于非活动期（P＜0．01）。活动期血浆ANA含量明显高于非活动期（P＜0．05）。外周血T淋巴细胞Fas阳性率与血浆ANA含量呈正相关。结果提示：在SLE发病过程中存在自身基因Fas的表达异常，Fas表达的增强反映SLE病人体内T淋巴细胞处于异常活化状态。
The expression of Fas on the T cells in patients with SLE and on that in the heathy control were measured by flow cytometry analysis Levels of serum ANA were investigated by means of ELISA. The results show that the levels of Fas expression on peripheral T cells in Six patients were significantly higher than that in the normal control (P < 0 .01 ). The differences of the levels of Fas expression between active and inactive SLE were significant (P < 0 .01 ). The results also shew that the levels of serum ANA in active SLE patients increasd significantly (P < 0. 05). By the analysis of the correlation between the levels of Fas expression on T cells and the levels of ANA in serum, a positive correlation is demonstrated for both active and inactive SLE. These observations suggest that the expression of Fas autogene is abnormal in the pathogenic progress of SLE. The increased expression of Fax on the peripheral T cells in SLE patients may reflect their unusual activated status in vitro.
出处
《苏州医学院学报》
1997年第6期1007-1009,共3页
Acta Academiae Medicinae Suzhou
