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CD34标记的微血管生成与原癌基因c-erbB-2在乳腺癌中的表达及其意义

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摘要 目的研究乳腺癌组织中微血管生成及原癌基因c-erbB-2的表达，分析两者之间的关系及其临床意义。方法应用S-P免疫组织化学染色方法，以CD34单克隆抗体标记65例乳腺癌肿瘤组织中微血管，计数微血管密度（MVD），同时检测肿瘤组织中c-erbB-2的表达，分析原癌基因c-erbB-2与血管生成及两者与肿瘤生物学行为的关系。结果肿瘤血管生成表现出明显的异质性，血管生成多见于肿瘤组织浸润边缘。MVD计数为3～33个／400倍视野（平均11．6±7．0），c-erbB-2阳性表达率为53．8％，MVD与c-erbB-2的表达无相关性（rs=0．100，t：0．905，P〉0．05），且两者与患者年龄、肿瘤大小、临床分期均不相关，仅MVD与肿瘤淋巴转移明显相关（rs=0．329，t=2．531，P〈0．05）。结论MVD与乳腺癌淋巴转移呈正相关，可作为预测乳腺癌淋巴转移的指标之一，对评估乳腺癌患者预后及指导术后治疗具有一定的意义。
作者 李洋 文壹 黄俊辉
机构地区 湖南省人民医院普外科 中南大学湘雅医院妇产科 肿瘤科
出处 《中国医师杂志》 CAS 2008年第9期1261-1263,共3页 Journal of Chinese Physician
关键词 基因 ERBB-2 毛细血管 抗原 CD3d 乳腺肿瘤/诊断
分类号 R737.9 [医药卫生—肿瘤]
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参考文献9

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中国医师杂志
2008年 第9期

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