摘要
该文以2,3-二羧酸吡啶为原料,经甲酯化、还原、氯代和环合等四步反应,首次用氯代产物在弱碱碳酸钾的作用下,常温环合反应5h,以78%的产率得到6-苄基-吡咯并[3,4-b]吡啶。该工作的新颖性已为2008年5月16日由教育部科技查新工作站(L06)出具的第L06-08077号《科技查新报告》所证实。
6-Benzylpyrrolo-[3, 4-b] pyridine, a key intermediate product of Moxifloxacin, was synthesized from pyridine-2, 3-dicarboxylic acid via esterification, reduction, chlorination and cyclization. The key cycliztion was attempted under room temperature, while the best yield of the reaction was 78%. The novelty of this research was testified by the Mininstry of Education Novelty Search Workstations （L06） on May 16.2008. The testified number was L06-08077.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2008年第10期1029-1030,共2页
Fine Chemicals
