摘要
目的探讨冠心病(CHD)合并焦虑障碍患者血浆神经肽Y(NPY)与心率变异性(HRV)的相关性。方法66例经选择性冠状动脉造影确诊为CHD的住院病人,通过Zung焦虑自评量表问卷调查分为焦虑障碍组(焦虑组,41例)和对照组(不伴焦虑障碍,30例)。运用放射免疫法检测患者血浆NPY含量,运用动态心电图系统采集患者的心电信号进行HRV分析。结果(1)与CHD患者比较,合并焦虑障碍的CHD患者血浆NPY水平均明显增高,具有统计学差异(P<0.05);(2)与CHD患者比较,合并焦虑障碍的CHD患者HRV指标SDNN、rMSSD、PNN50明显降低,具有统计学差异(P<0.05);(3)CHD并焦虑障碍患者血NPY与HRV呈负相关。结论CHD并焦虑障碍患者血NPY增高与HRV降低密切相关。
Objective To study the relation between plasma neuropeptide Y（NPY） and heart rate variability（HRV） in CHD with anxiety neurosis. Methods In-patients diagnosed by coronary angiography,separated 30 cases as control group and 41 cases as anxiety group by Self-Rating Anxiety Scale. Using radioimmunoassay method to detect the plasma NPY and detecting the electrocardiograph signal of dynamic cardiogrms to analyse the heart rate variability. Results The levels of plasma NPY was significantly higher in CHD with anxiety neurosis than those in ecumenic CHD patients（P 〈 0.05 ）. There were significant difference between both group in HRV（P 〈 0.05 ）. HRV was lower in anxiety group than control group. The plasma NPY and HRV were negatively relation. Conclusion The plasma NPY and HRV are negative relation in CHD with anxiety.
出处
《中国现代医生》
2008年第29期29-30,共2页
China Modern Doctor
基金
贵州省优秀科技教育人才省长资金项目(2005)306号
