摘要
目的初步分析孕妇血清标记物甲胎球蛋白和绒毛膜促性腺激素β亚基对胎儿唐氏综合征的产前筛查作用。方法采用时间分辨免疫荧光法,检测15～20周6d孕妇血清AFP和F-β-HCG浓度,结合孕妇年龄、孕周、体重,利用计算机软件,计算胎儿患唐氏综合征的风险率。结果筛查1614例孕妇,检出DS高危82例,占受检人数的5.1%;开放型神经管缺陷高危8例,占受检人数0.5%;18-三体高危2例,占受检人数0.1%;假阳性率为5%。结论检测孕中期孕母血清AFP和β-HCG两项指标进行产前筛查,对发现胎儿先天缺陷、预防唐氏综合征有重要作用。
Objective To investigate the effect of maternal serum markers AFP-HCG for prenatal screening of down syndrome. Methods Used a method based on detecting maternal serum alpha fetoprotein（AFP） and free beta-human chorionic gonadotrophin（F-β-HCG） concentrations in the women of 15-20 weeks and six days pregnanee in combination with maternal age and gestafional age and weight. Pregnant women at risk for fetal DS were identified by analyses of computer software. Results Among 1614 pregnant women, 82 cases （5.1% ） were at high risk for DS,8 cases（0.5%） were at high risk for NTD,2 cases（0.1%） were at high risk for 18-three body. Conclusion Prenatal screening by using of medium maternal serum markers AFP-HCG can provide sudstantial advantages for down syndrome.
出处
《中国现代医生》
2008年第29期20-21,共2页
China Modern Doctor
