摘要
目的探讨赖诺普利治疗慢性心力衰竭患者血浆NT-proBNP水平和超声心动图Tei指数的变化和意义。方法观察171例慢性心力衰竭心功能III～IV级患者,分别给予赖诺普利和赖诺普利联合卡维地洛治疗8周后,检测血浆NT-proBNP水平和超声心动图Tei指数及LVEF的变化。结果赖诺普利联合卡维地洛治疗组患者血浆NT-proBNP水平明显低于单纯赖诺普利治疗组(P<0.05),同时赖诺普利联合卡维地洛治疗组患者超声心动图Tei指数较单独赖诺普利治疗组明显降低(P<0.05)。结论ACE-I联合非选择性β受体阻滞剂治疗慢性心力衰竭明显优于单纯应用ACE-I。
Objective To investigate the change and significance of plasma NT-proBNP and Tei index in patients with chronic cardiac failure treated with lisinopril and carvedilo. Methods One hundred and seventy one patients with chronic cardiac failure（cardiac functional grading from III to IV） were divided into two groups, one group treated with lisinopril and carvedilo, the other group treated single with lisinopril. After eight weeks the level of plasma NT-proBNP,Tei index and LVEF were detected. Results The level of plasma NT-proBNP in lisinopril association carvedilo group was fewer than in lisinopril group. And the same in Tei index. There was significant difference between two groups（P〈 0.05）. Conclusion ACE-Ⅰ and non-selectivity β acceptor blocker are better than single ACE-Ⅰ in the treatment of the patients with chronic cardiac failure.
出处
《中国现代医生》
2008年第29期4-5,共2页
China Modern Doctor
