摘要
采用Ｗｉｓｔａｒ大鼠腹腔注射青霉素，造成实验性癫痫模型，对大鼠痫性发作的行为改变、海马和大脑皮质的电生理变化以及双氢吡啶类钙通道阻滞剂尼莫地平的抗痫作用进行了观察。结果显示：尼莫地平能明显抑制大鼠痫性放电和痫性发作，预先腹腔注射尼莫地平再给予青霉素则不出现痫性活动。
Injecting penicillin (PNC) intraperitoneally in Wistar rats, we observed their epileptic behaviour and electroencephalographys. The results showed that nimodipine (NIM), a calcium antagonist, could inhibit the seizures and epileptic discharges significantly. No epileptic action was noted while NIM was injected before PNC. It supports our consideration of NIM as a new sort of nonsedative anticonvulsant in clinical practice.
出处
《华西医科大学学报》
CSCD
1997年第4期383-387,共5页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
