摘要
为了解中国汉族Ｃ１Ｒ的遗传多态性，采用聚丙烯酰胺等电聚焦结合免疫斑点转移的方法检测了３个城市中无亲缘关系的３１７名中国汉族献血员（吉林市１０５人，成都市１１１人，广州市１０１人）的Ｃ１Ｒ表现型。结果显示：这三个汉族群体均有Ｃ１Ｒ＊１、Ｃ１Ｒ＊２和Ｃ１Ｒ＊５等三个常见等位基因。其频率分别为：吉林，Ｃ１Ｒ＊１＝０．５３８１，Ｃ１Ｒ＊２＝０．２６１９，Ｃ１Ｒ＊５＝０．１７１４；成都，Ｃ１Ｒ＊１＝０．５６７６，Ｃ１Ｒ＊２＝０．３４２３，Ｃ１Ｒ＊５＝０．０８５６；广州，Ｃ１Ｒ＊１＝０．５２４８，Ｃ１Ｒ＊２＝０．３６６３，Ｃ１Ｒ＊５＝０．１０８９。同时还发现了Ｃ１Ｒ＊６、Ｃ１Ｒ＊７、Ｃ１Ｒ＊８等三个稀有基因。由此可见，在中国汉族人群中，Ｃ１Ｒ＊２的频率从北向南逐渐上升。说明可能存在地理渐变群（Ｃｌｉｎｅ）。在中国汉族，其累积杂合度达６１．５１％。
To reveal the C1R polymorphism in Chinese, three Han populations in Guangzhou (101 samples), Jilin (105 samples) and Chengdu (111 samples) were investigated with a technique using PAGIF followed by immunoblotting. The results showed in Chengdu the C1R*1=0.5676, C1R*2=0.3424 and C1R*5=0.0856, in Guangzhou C1R*1=0.5248, C1R*2=0.2663 and C1R*5=0.1089, and in Jilin C1R*1=0.5381, C1R*2=0.2619 and C1R*5=0.1714. Three rare genes C1R*6, C1R*7 and C1R*8 were found in the investigation. These indicate that the frequency of C1R*2 is elevated from north to south which may imply a geographic cline in this locus. The cumulated heterogeneity of C1R in Han population is 61.5% which means that this polymorphic system is useful in anthropolgy as well as in forensic science.
出处
《华西医科大学学报》
CSCD
1997年第4期372-374,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
纽约中华医学基金
