摘要
应用ＲＴ－ＰＣＲ方法，研究ＨＧＶ感染及复制与ＨＣＣ家庭聚集关系。结果发现，高发家庭成员和低发家庭成员中的ＨＧＶＲＮＡ阳性率分别为３６．４％（２０／５５）和１４．５％（８／５５），经统计学分析有非常显著性差异（Ｐ＜０．０１）。同时还发现肝癌家庭成员中ＨＧＶＲＮＡ也呈家庭聚集现象。提示，ＨＧＶ感染形成的家庭聚集性及复制状态，可能是ＨＣＣ家庭聚集原因之一。ＨＧＶ可能是继ＨＢＶ、ＨＣＶ之后发现的又一种与ＨＣＣ发生关系密切的新型肝炎病毒。
RT-PCR technique was aplied to investigate the relationship between familial cluster of HCC and HGV infection The results showed that the positive rates of HGV RNA in the members of high HCC occurence families and in the members of low HCC occurence families were 36 4%(20/55) and 14 5%(8/55) respectively,and the difference between these two groups was very significant (P<0 01) Furthermore,members of HCC families also showed the phenomenum of HGV RNA familial cluster This study suggests that familial cluster of HGV infection and replication may be one of the causes of familial cluster of HCC HGV appears to be another virus besides HBV and HCV,which is related closely to the pathogenesis of HCC
出处
《广西医科大学学报》
CAS
1997年第3期20-23,共4页
Journal of Guangxi Medical University
