摘要
目的：通过尿液三种尿蛋白含量测定，以早期诊断肾损害。方法：采用放射免疫测定法（ＲＩＡ），对５０例健康者、１４４例高血压病和１１３例Ⅱ型糖尿病患者尿α１微球蛋白（α１ＭＧ）、白蛋白（Ａｌｂ）及丝状糖蛋白（ＴＨＰ）联合检测，并与内生肌酐清除率（ＣＣｒ）进行比较。结果：当ＣＣｒ＞１００ｍｌ／ｍｉｎ时，α１ＭＧ排泄水平已明显增加（Ｐ＜０．０１）。Ａｌｂ和ＴＨＰ则在ＣＣｒ＜１００ｍｌ／ｍｉｎ时排泄量才有明显改变（Ｐ＜０．０１）。三种尿微量蛋白均与ＣＣｒ相关（Ｐ＜０．０１）。糖尿病组较高血压病组Ａｌｂ水平显著增高。结论：尿微量蛋白检测是早期诊断肾损害的敏感指标，其测定值可反映肾功能状况。
Objective:To study the clinical significance of the urine excretion levels of alpha l microglobulin(α 1 MG),albumin(Alb) and Tamm Horsfall protein(THP) in patients with essential hypertension(EH) and non insulin dependent diabetes mellitus(NIDDM).Methods:Radioimmunoassay(RIA) was used for measuring α 1 MG,Alb and THP in normal individuals and patients with EH and DM.Results:The results showed that the urine levels of Alb in patients with NIDDM were higher than that in patients with EH( P <0.01).Uirinary levels of α 1 MG elevated significantly when the endogenous creatinine clearance rate(CCr) was>100 ml/min( P <0.01).Whereas Alb and THR elevated when CCr was<100 ml/min.Conclusions:The urine microprotein detection is very sensitive in early renal damage of patients with EH and NIDDM.
出处
《蚌埠医学院学报》
CAS
1997年第6期431-433,共3页
Journal of Bengbu Medical College
关键词
高血压
糖尿病
尿液
肾损害
Α1-MG
白蛋白
urine
alpha l microglobulin(α 1 MG)
albumin
Tamm Horsfall protein
hypertension
diabetes millitus
