摘要
背景:目前常见的乳腺增生症的诊断方法都存在着局限性,课题组在由金宗浩组织的全国百万妇女乳腺防癌筛查过程中,提出了一种基于体内热估计技术筛查乳腺增生症的方法。目的:评价体内热估计技术在大规模人群体检中筛查妇女乳腺增生症中的应用价值。设计、时间及地点:病例-对照观察,于2008-03/06在同济大学生物医学信息与生物控制实验室完成。参试者:临床乳腺外科医生从上海宝山地区参加妇女乳腺疾病普查5000余例中划分出的健康人和乳腺增生症患者。方法:受试者在20～24℃室温下裸露受检部位20min以上使皮肤适应室温,用日本NECsan-ei Instruments,Ltd.制TH5108ME型红外热像仪距裸露前胸约50cm处摄取两乳房正面和左、右乳房3张图片,然后用计算机进行体内热估计处理,再人工筛查出异常图片,并对异常图片进行计算机参数计算和特征提取,根据特征参数人工筛查出乳腺增生症患者。主要观察指标:乳腺增生患者与健康者的两侧乳头温差、左右乳房平均温差、单侧最高温点与其对称点的温差比较。结果:与健康组比较,乳腺增生组各特征数据明显增高。通过以上5000余例乳腺疾病普查验证,还未出现漏诊的情况。结论:体内热估计技术是一种非接触式的、无放射线辐射的检查方法,操作简便、成本低、安全准确,非常适合在大规模人群体检中对妇女进行乳腺增生症的筛查。
BACKGROUND： Current common diagnosis methods for mastoplasia have limitations. In the national millions of women mammary gland cancer screening by Jin Zong-hao, an inside thermal estimation-based method was proposed.
OBJECTIVE： To evaluate the application value of inside thermal estimation technique in screening mammary gland cancer of large sample.
DESIGN, TIME AND SETTING： Case-contrast observation was performed at the Biomedical Information and Biological Control Laboratory of Tongji University from March to June 2008.
PARTICIPANTS： Health people and patients with mastoplasia, who participated in the census of women breast disease in 5 000 cases from Shanghai Baoshan district, were screened by breast surgeon.
METHODS： Participants bare chest at 20-24℃ for more than 20 minutes, then infrared imaging system, about 50 cm from the bare chest, was used to shoot 3 infrared thermal images of front, left and right sides. Inside thermal estimaion was performed using computer, and abnormal images were screened manually for feature extraction and parameter calculation to screen mastoplasia.
MAIN OUTCOME MEASURES： Temperature difference between two nipples, two sides of the breast, and between the highest temperature point and the symmetric point.
RESULTS： Compared with healthy people, all feature parameters of mastoplasia patients are significantly higher. Missed diagnosis did not occur during the whole screening.
CONCLUSION： ITE technology is an untouched and non-radiated method, and is simple, low-cost and safe. It can be used for screening of mammary gland cancer of large sample.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第39期7645-7648,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
日本NECsan-eiInstruments
Ltd.国际合作项目(2000239001)~~
