摘要
组织工程角膜内皮载体材料的研究历程,总体上经历了从天然材料到人造材料,然后再回到天然材料这样一个循环,取得了宝贵的正反两方面经验。早期开始使用的材料主要有:异体角膜片、明胶薄膜、胶原凝胶、聚羟基乙酸和聚乳酸羟基乙酸、水凝胶膜等,而角膜基质/后弹力膜、羊膜基底膜、角膜基质片、复合生物膜是目前的研究热点。改善材料的亲细胞性、免疫原性和降解/溶解特性是今后的发展方向,并且应该加强对材料的人体效应和远期影响的研究。
The study course of carrier material for bioengineered corneal endothelium generally goes through a circulation of natural material-artificial material-natural material and attains valuable satisfactory and dissatisfactory experience. The early used materials include heterologous cornea, collagen, gelatin membrane, hydrogel, polyglycolic acid, poly lacticoglycolic acid, and so on. Corneal stroma/posterior elastic membrane, amniotic basilar membrane, corneal stroma, and poly-biomembrane are current study hotspots. The further development in this field is to improve the cytophile, immunogenicity, and biodegradation. It is necessary to investigate the long-term effect on human body so as to promote the clinical application of cultivated corneal endothelium transplantation in the future.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第36期7191-7194,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
