摘要
目的评估电针刺激内关穴fMRI脑区激活的可重复性。方法健康成人志愿者6例，在不同时间行3次fMRI检查，每次每人分别接受右手简单对指（以下简称对指组）和电针刺激右侧内关穴（以下简称电针组）两项任务。通过计算3个不同时间3次fMRI检查激活脑区体积的重叠率（Roverlap）和兴趣区（ROIs）内脑区激活强度的组内相关系数（ICC），对2项任务fMRI的可重复性进行评估。结果对指组激活脑区体积的Roverlap（54．24±9．49）显著高于电针组的Roverlap（13．234-14．21）；对指组ROIs内信号强度ICC（0．69～0．80）显著高于电针组ROIs内信号强度ICC（0．18～0．68）；说明对指组脑区激活的可靠性较电针组高。对指组ROIs内激活信号强度显著高于电针组，说明对指组fMRI脑区激活的信噪比较电针组高。结论相对于简单对指任务较为稳定的脑区激活，电针内关穴fMRI激活脑区和激活强度变异较大。电针内关穴fMRI激活脑区相对低的信噪比和低的敏感性是引起电针刺激重复性差的主要可能原因。将个体的功能数据进行组化研究，有助于提高电针内关穴fMRI的敏感性，提高激活脑区的可重复性。
Objective To assess the reproducibility of brain activation by functional MR imaging during electroaeupuncture stimulation at PC6 （neiguan）. Methods Six healthy adult volunteers participated in three identical scan sessions during different interval time. Each scan session consists of two functional tasks, an electroaeupuncture stimulation （2 Hz） at PC6 and a control task of simple finger tapping. The reproducibility of brain responses was analyzed in terms of the overlap ratio of active volume within sessions and the ICC of active signal intensity in ROIs. Results The Roverlap of the simple finger tapping task （ 34.24 ± 9.49 ） was significantly higher than that of the electroaeupuncture stimulation task. （13.23 ± 14.21 ）. The range of ICC of ROIs in the simple finger tapping task （0.69 - 0. 80 ） was significantly higher than that of the electroacupuneture stimulation task （0.18 -0.68）. The results above showed that the reliability of brain activation in the finger tapping task group was higher than that in the electroacupuncture stimulation task group. The active intensity of ROIs in the simple finger tapping task was significantly higher than that in the electroacupuncture stimulation task, indicating the signal to noise ratio of brain activation in the finger tapping task group was higher than that in the electroacupuncture stimulation task group. Conclusion In contrast to the relatively reliable activation evoked by the simple finger tapping task, the activation evoked by electroacupuncture stimulation task was much more variable. The main possible reason is that the relatively low signal to noise ratio of brain activation on fMRI and low sensitivity caused the lower reproducibility of electroacupuncture stimulation task. The group analysis in combination with the individual functional data may be utilized to improve the reproducibility of fMRI evoked by eleetroacupuneture stimulation at PC6 （neiguan）.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2008年第20期1878-1882,共5页
Journal of Third Military Medical University
关键词
电针
功能磁共振成像
可重复性
内关穴
脑
electroacupuncture
fMRI
reproducibility
neiguan （PC6）
brain
