摘要
目的：探讨系统性红斑狼疮（ＳＬＥ）孕妇在ＳＬＥ稳定期外周血中的Ｔ淋巴细胞亚群、自然杀伤细胞（ＮＫ细胞）及可溶性血清白细胞介素－２受体（ＳＩＬ－２Ｒ）的改变。方法：采用流式细胞仪对１４例ＳＬＥ稳定期（仅服用小剂量激素）的患者妊娠时（ＳＬＥ＋ＮＰ组）的Ｔ细胞亚群和ＮＫ细胞进行检测，同时用固相酶联反应法（ＥＬＩＳＡ）检测其ＳＩＬ－２Ｒ。并以１８例稳定期ＳＬＥ未孕妇女（ＳＬＥ组）、２０例正常未孕妇女（ＮＮＰ组）和２０例正常孕妇（ＮＰ组）作对照。结果：ＳＬＥ＋ＮＰ组的辅助性－诱导性Ｔ细胞（ＣＤ４＋）细胞数量较其他３组有明显下降（Ｐ＜０．０１）；ＣＤ４＋／细胞毒性－抑制性Ｔ细胞（ＣＤ８＋）值，ＳＬＥ＋ＮＰ组较ＳＬＥ组和ＮＮＰ组有显著下降（Ｐ＜０．０１），ＮＰ组也有下降，ＳＬＥ＋ＮＰ组和ＮＰ组之间差异无显著性（Ｐ＞０．０５）。ＮＫ细胞数在４组间差异无显著性（Ｐ＞０．０５）；ＳＬＥ＋ＮＰ组ＳＩＬ－２Ｒ有明显增高（Ｐ＜０．０１），其他３组变化不显著（Ｐ＞０．０５）。
Objective: To determine the changes of T lymphocyte subsets, natural killer (NK) cell and serum interleukin2 receptor (SIL2R) in peripheral blood of the pregnant women with systemic lupus erythematosus (SLE). Methods: T lymphocyte subsets, NK cell, and SIL2R in peripheral blood were detected by flow cytometry (FCM) and enzymelabeled immunosorbent assay (ELISA) in 14 cases of pregnant women complicated by SLE (SLE+NP), 18 cases of stationary phase SLE (SLE), 20 cases of normal nonpregnant women (NNP) and 20 cases of normal pregnant women (NP). Results: The percentages of CD4+ cell were decreased significantly in SLE+NP group as compared with the other three groups (P<0.01); and the ratio of CD4+/CD8+ was decreased significantly in SLE+NP group, as compared that in SLE group and in NNP group (P<0.01). There were no difference in the number of NK cells among the four groups. The SIL2R values were found to be increased significantly in the SLE+NP group, as compared with that of other three groups (P<0.01). Conclusions: The observation on the changes of peripheral T lymphocyte subsets and SIL2R may be helpful for monitoring progress of SLE during pregnancy.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第11期671-673,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
红斑狼疮
SLE
T细胞亚群
白细胞介素2
Lupus erythematosus
systemic
Tlymphocyte subsets
Killer cells
naturalReceptors
interleukin2
