摘要
目的：探讨米索前列醇用于足月妊娠引产的安全性及效果。方法：将６０例有引产指征的孕足月单胎头位、无宫缩的初产妇，随机分成两组，研究组（３０例）用米索前列醇５０μｇ阴道用药，每３小时１次至正式临产；对照组（３０例）用蓖麻油鸡蛋餐口服。结果：两组引产总有效率无显著差异，研究组引产时间显著少于对照组（Ｐ＜０．０５），研究组需静脉滴注催产素人数为１０．０％，显著少于对照组的４０．０％，（Ｐ＜０．０５），用药６小时后研究组宫颈评分提高５．５分，对照组提高３．１分，评分结果比较，差异有显著性（Ｐ＜０．０５），研究组子宫收缩过频的发生率为１６．７％，对照组为３．０％。结论：阴道放置米索前列醇用于足月妊娠引产能促宫颈成熟及发动子宫收缩，是安全。
Objective: To compare the safety and efficacy of intravaginal prostaglandin E1, misoprostol with ricinus oil meal for labor induction. Methods: Sixty patients with an indication for induction of labor were randomly assigned to two groups (30 cases each) induction with misoprotol, 50 μg intra vaginally every 3 hours until active labor, or with that ricinus oil meal was taken. Results: The time from start of induction to vaginal delivery was significantly shorter in the misoprostol group (12.2 vs 18.1, P<0.05), and fewer patients in the misoprostol group required oxytocin augmentation (10.0% vs 40.0%, P<0.05). The mean change in the Bishop score was significantly higher in those receiving misoprostol (5.5 vs 3.1, P<0.05). Uterine tachysystole occurred more frequently in patients in the misoprostol group (16.7%) than in the ricinus oil meal group (3.0%). No significant differences were noted in the mode of delivery and patients of successful labor induction. Conclusions: Vaginally administered misoprostol is an effective agent for the cervical ripening and induction of labor.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第11期666-668,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
米索前列醇
药物引产
足月妊娠
Misoprostol Labor, inducted Uterine contraction
