摘要
目的：探讨胎儿胎盘产物甲胎蛋白（ＡＦＰ）、游离雌三醇（ｕＥ３）和β绒毛膜促性腺激素（β－ｈＣＧ）水平与胎儿唐氏综合征发病的关系。方法：用放射免疫法测定１７例妊娠唐氏综合征胎儿的孕妇（病例组）和１３１例妊娠正常胎儿孕妇（对照组）的外周血、羊水及脐血中ＡＦＰ、ｕＥ３和β－ｈＣＧ水平。结果：病例组孕妇外周血、羊水和脐血中ＡＦＰ水平均低于对照组（Ｐ＜０．０５）；ｕＥ３水平也均低于对照组（Ｐ＜０．０５）；β－ｈＣＧ水平均高于对照组（Ｐ＜０．０５）。结论：检测孕妇外周血中ＡＦＰ、ｕＥ３。
Objective: To investigate the relationship between fetal trisomy 21 and alpha fetoprotein (AFP), unconjugated oestriol (uE3) and β human chorionic gonadotropin (βhCG) levels in maternal serum, amniotic fluid and fetal serum. Method: AFP, uE3 and βhCG levels in maternal serum, amniotic fluid and fetal serum from 17 pregnancies with fetal trisomy 21 and 131 unaffected control pregnancies were measured between 16 to 28 weeks gestation using radioimmunoassy. Results: In these pregnancies with fetal trisomy 21, the AFP and uE3 levels in maternal serum, amniotic fluid and fetal serum were lower than those in controls; but βhCG levels were higher (P<0.05). Conclusions: To measure maternal serum AFP, uE3 and βhCG levels will be useful in prenatal detection of trisomy 21.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第11期655-658,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
甲胎蛋白
雌三醇
唐氏综合征
产前诊断
胎儿
Alpha fetoproteins
Estriol
Gonadotropins
chorionic
Down syndrome
