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冠心病患者循环内皮细胞中人类巨细胞病毒-DNA检测及临床意义 被引量：2

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摘要 目的研究冠心病患者循环内皮细胞(CEC)中人类巨细胞病毒-DNA(HCMV-DNA)的临床意义。方法对43例冠心病患者(CHD组),17例其他心脏病患者(心脏病组)和28例健康体检者(对照组)的CEC进行检测,并运用荧光定量PCR方法对CEC的HCMV-DNA进行分析。结果CHD组CEC数〔(7.2±3.1)个/0.9μl〕明显高于心脏病组〔(3.9±2.1)个/0.9μl〕和对照组〔(3.6±2.0)个/0.9μl〕,且CHD组CEC的HC-MV-DNA检出率(30.2%)明显高于对照组(10.7%)以及心脏病组(11.7%)。结论HCMV感染血管内皮细胞可能是冠心病患者CEC增高的原因之一,这可能在HCMV致冠状动脉粥样硬化性心脏病发病过程中具有重要作用。
作者 姚磊 朱沂 余鹃春 董解菊
机构地区 第三军医大学新桥医院检验科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第18期1818-1819,共2页 Chinese Journal of Gerontology
关键词 冠心病 循环内皮细胞 HCMV-DNA 定量PCR
分类号 Q813.111 [生物学—生物工程]
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参考文献13

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共引文献8

同被引文献17

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引证文献2

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中国老年学杂志
2008年 第18期

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