摘要
目的:探讨肾虚型早期SA与PR的相关性,分析其中医肾虚证型规律,以揭示肾虚型自然流产的部分实质。方法:选择肾虚型早期自然流产清宫孕妇11例为实验组,设立非肾虚型早期自然流产清宫孕妇20例和正常早期妊娠要求人工流产者10例为对照组。运用RT-PCR方法检测蜕膜PRmRNA的表达。结果:肾虚型早期自然流产患者蜕膜PR的表达明显低于正常早孕要求人工流产的患者(P<0.01),同时也发现其表达明显低于非肾虚型早期自然流产的患者PR的表达(P<0.01)。结论:通过研究,发现蜕膜PR低表达与肾虚型早期自然流产的发生有着密切的关系。
Objective：To study the Progestogen Receptor expression in the deciduas so as to explore the mechanism of the kidney deficiency early pregnant women with ,spontaneous abortion. Methods ： 11 patients were diagnosed as spontaneous abortion and the kidney deficiency in the first trimester in the 1st Affiliated Hospital,Guangzhou University of TCM. These patients deciduas and the other deciduas from 20 women diagnosed as spontaneous abortion and the blood stasis （ or blood fever） in the same period as well as 10 normal early pregnancy women who desired conducting induced abortion were collected. RT - PCR were used to detect the expression of PPmRNA in the deciduas. Results：The expression of PRmRNA in the deeiduas every group were different, the different was significant （ P 〈 0.01 ）, the expression of the kidney deficiency early pregnant women with spontaneous abortion was lowest（ P 〈 0.01 ）. Conclusion ：In the clinical research ,the normal expression of PRmRNA in the deeiduas are important in maintaining early pregnancy. The lower expression is related elosely to the kidney deficiency early pregnant women with spontaneous abortion.
出处
《中华中医药学刊》
CAS
2008年第10期2162-2163,共2页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(30271632)
关键词
肾虚
自然流产
蜕膜PR
Kidney deficiency
spontaneous abortion
Progestogen
Receptor
