摘要
目的:以网织血小板(RP)百分比代表血小板更新率,研究RP百分比与阿司匹林抵抗(AR)发生率之间的关系,阐明血小板更新率对AR的影响。方法:选取80名服用阿司匹林的患者,测定其服用阿司匹林(100mg.d-1)≥7d后的RP百分比以及在花生四烯酸(AA)、二磷酸腺苷(ADP)诱导下的血小板聚集率。将患者分为AR组、阿司匹林半抵抗(ASR)组、阿司匹林敏感(AS)组,比较AR、ASR、AS3组之间RP百分比的差异是否有统计学意义。结果:AR、ASR、AS3组RP百分比分别为(4.11±2.62)%、(2.23±1.79)%、(2.18±1.24)%,AR、AS组之间RP百分比有显著性差异(P<0.05),AR、ASR组之间RP百分比有显著性差异(P<0.05),ASR、AS组之间RP百分比无显著性差异(P>0.05)。结论:血小板更新率增加可能会导致AR,冠心病患者可能需要在1天内多次服用阿司匹林抗血小板治疗,或将阿司匹林改为控释或缓释剂型,建议对这些疗法的安全性和有效性进行临床试验来验证。
OBJECTIVE： To study the association between the reticulated platelets （RP） percentage and aspirin resistance （AR） with the percentage of reticulated platelets in whole blood representing the platelets turnover rate to illuminate the influence of platelets turnover rate on AR. METHODS： The RP percentage and arachidonic acid （AA） and adenosine diphosphate（ADP） - induced platelet aggregation in 80 patients after receiving aspirin （100 mg· day） for no less than 7 days were determined. The patients were divided into AR group, aspirin semi - resistance （ASR） group, and aspirin sensitive （AS） group, and the RP percentage in the three groups were compared. RESULTS： RP percentages in AR, ASR, and AS groups were （4.11 ± 2.62） %, （2.23 ± 1.79） %, and （2.18 ± 1.24） %, respectively, showing signficant differneces between AR group and AS group （P〈0.05） and between AR group and ASR group （P〈0.05）, but the difference of RP percentage between ASR group and AS group was not significant （P 〉0.05）. CONCLUSION： Increased platelets turnover may induce AR, therefore, the patients with coronary artery disease should receive aspirn for multiple daily （antiplatelet therapy） or to take controlled release or sustained release aspirin. The safety and efficacy of these therapies should be confirmed in clinical trials.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第29期2280-2282,共3页
China Pharmacy
基金
上海市卫生局基金资助项目(044018)
关键词
阿司匹林抵抗
血小板更新率
网织血小板
Aspirin resistance
Platelet turnover rate
Reticulated platelets
