摘要
目的:考察盐酸多巴胺注射液与单硝酸异山梨酯注射液在葡萄糖注射液中的配伍稳定性。方法:监测盐酸多巴胺注射液与单硝酸异山梨酯注射液配伍后于20、30℃时自然光照射下24h内的含量变化,同时考察配伍液pH值与外观的变化情况。结果:二者配伍后18h内外观、pH值、含量无显著变化。结论:盐酸多巴胺注射液与单硝酸异山梨酯注射液在20、30℃下可配伍用于静脉滴注,但宜在18h内使用完毕。
OBJECTIVE： To investigate the compatible stability of isosorbide mononitrate （ISO） and dopamine （DA） hydrochioride in glucose injection. METHODS： The contents of ISO and DA in the mixture of ISO and DA at 20 ℃ and 30 ℃ under natural illumination within 24 h, and the pH and appearance of the mixture were monitored. RESULTS： No significant change was noted in the concentrations of ISO and DA, the pH and the appearance of the mixture at 20 ℃ or 30 ℃ . CONCLUSION： The mixture of ISO and DA in glucose injection was stable at 20 ℃ or 30 ℃, but which should be used up within 18 h after mixing.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第29期2278-2280,共3页
China Pharmacy
