摘要
为了从血清结合珠蛋白（Ｈａｐｔｏｇｌｏｂｉｎ，Ｈｐ）的遗传多态现象探讨复发性口疮发生的遗传易感性，本研究对１０８例复发性口疮患者进行了Ｈｐ型别测定并分析基因频率，与正常对照组进行比较分析。结果发现正常人对照组血清Ｈｐ２－２表型频率为０．５３７、Ｈｐ２－１０．３７２、Ｈｐ１－１０．０８４。１０８例复发性口疮患者血清Ｈｐ２－２为０．４９０、Ｈｐ２－１０．４１７、Ｈｐ１－１０．０５５。患者组Ｈｐ２－１表型频率高于正常对照组，经ｘ２检验，差异有显著性（Ｐ＜０．０５）。结果表明带有Ｈｐ２－１表型的人群可能对复发性口疮有遗传易感性。提示对于带有血清Ｈｐ２－１表型的人群应加强保护措施，避免环境因素的影响，从而降低复发性口疮的发病率。
To probe into recurrent aphthous ulceration genetic sensitivity on the basis of serum haptoglobins genetic polymorphism,serum haptoglobin phenotypes were determined in 108 patients with recurrent aphthous ulceration,their gene frequency was analyzed in comparison with a control group.The results showed that the phenotype frequency of Hp 2-2 in the control group was 0.537 ,Hp 2-1 was 0.372 ,Hp 1-1 was 0.084 .The phenotype frequeny of Hp 2-2 in the patient group was 0.490,Hp 2-1 was 0.417 ,Hp 1-1 was 0.055 .The phenotype frequency of Hp 2-1 in the patients was higher than that of Hp 2-1 in the control group.Tested by x 2,the difference was remarkable(P< 0.05 ),suggesting that susceptibility to recurrent aphthous ulceration may exist in the persons of Hp 2-1 .The results pointed out that the persons of phenotypes of Hp 2-1 should be protected by some measures and some effects of environmental factors avoided to reduce incidence of the disease.
出处
《河北医科大学学报》
CAS
1997年第6期321-324,共4页
Journal of Hebei Medical University
基金
河北省卫生厅科研基金
关键词
血清结合珠蛋白
复发性口疮
遗传学
serum haptoglobin
recurrent aphthous ulceration
genetics
