摘要
本文运用ABC免疫组化结合图象分析，定量分析了PCNA（细胞增殖核抗原）和P53在口腔鳞癌中的表达。探讨了两者在口腔鳞癌的临床病理、肿瘤侵袭和转移等方面的异同点。结果表明：PCNA的表达强度和阳性率与肿瘤的病理分级有关，与肿瘤细胞的侵袭转移无关。而P53和肿瘤细胞的侵袭有着密切的关系（P＜0．05）。P53阳性者，淋巴结转移率较高（60％），而P53阴性者，淋巴转移率为29％。在临床预后较差的颊癌，P53的阳性率较高（80％）。结果表明在口腔鳞癌的临床行为恶性，预后等方面定量分析上述指标有着十分重要的意义。
We have studied expression of the PCNA and P53 protein in oral squamous cells carcinoma by ABC immunhistochemical technique,and analyzed the characteristic about clinical pathological parameters and metastasis between them. This result showed PCNA expression were corrected with tumour grading, but not with tumour invasion. There was strong correlation between P53 over expression and tumour invasion and lymph node metastasis. P53 positive tumours have highly lymph node metastasis (60% ),but P53 negative tumours have lower (29% ). Overexpression of P53 was found to be relatively higher,although not satistically significant in buccal mucosa than in other sites. P53 and PCNA may be an useful indication to the clinician to predict tumour behavior and prognosis.
出处
《上海口腔医学》
CAS
CSCD
1997年第4期208-212,共5页
Shanghai Journal of Stomatology
关键词
增殖细胞核抗原
免疫组织化学
鳞癌
口腔肿瘤
cell proliferation of nuclear antigen P53 immunohistochemistry of oral squamous cells carcinoma
