摘要
为探讨链脲菌素脑室内注射大鼠建立的Ａｌｚｈｅｉｍｅｒ病模型脑组织的损伤机制和乙酰肉毒碱的神经保护作用，测定脑中隔和海马回α－酮戊二酸脱氢酶（α－ＫＧＤＨ）、谷氨酸脱氢酶（ＧＬＤＨ）、胆碱乙酰基转移酶（ＣｈＡＴ）、肉毒碱乙酰基转移酶（ＣＡＴ）的酶活性。结果显示，脑中隔α－ＫＧＤＨ和ＧＬＤＨ活性均下降，并且酶活性的降低与中隔重量的减轻具有高度相关性。乙酰肉毒碱能提高海马回被链脲菌素降低的ＣｈＡＴ的活性。提示链脲菌素是通过对脑组织的损伤作用影响酶活性的；乙酰肉毒碱对脑组织具有神经保护作用。
The purpose of this study was to investigate the mechanism of brain damage after intracerebroventricular injection of streptozotocin in rat model for Alzheimer's disease and of the neuroprotective effect of acetylLcarnitine. The activities of αketoglutarate dehydrogenase (αKGDH), glutamate dehydrogenase (GLDH) choline acetyltransferase (ChAT), carnitine acetyltransferase (CAT) activities in the septum and hippocampus were determined. The results of the study were that the activities of αKGDH and GLDH reduced in septum, and significant correlation was found between septal weight and the enzyme activities. AcetylLcarnitine partly prevented the damage, as reflected by an attenuation of the streptozotocininduced decrease in hippocampal ChAT. The results suggest that the effect of streptozotocin on the brain enzyme activities is due to the damage of brain tissues caused by streptozotocin, and acetylLcarnitine has the neuroprotective effect against this damage.
出处
《中华精神科杂志》
CSCD
1997年第4期228-230,共3页
Chinese Journal of Psychiatry
关键词
乙酰肉碱
氧化还原酶类
早老性痴呆
Alzheimer's disease
Acetyl carnitine
Disease models
animal
Streptozotocin
Oxidoreductases
Choline acetyltransferase
