摘要
目的观察血清促红细胞生成素(EPO)水平与急性心肌梗死(AMI)直接经皮冠状动脉介入(PCI)治疗后梗死面积的关系。方法初次急性ST段抬高型心肌梗死86例,在发病12 h内成功地接受了PCI的患者测定血清EPO和肌酸肌酶(CK),并计算其CK累积释放量。以EPO中间值(19.6 U/L)分为高EPO组[(39±17)U/L]和低EPO组[(14±4)U/L],对两组CK累计释放量进行比较,并对CK累积释放量的可能影响因素做多元逐步回归分析。结果CK累积释放量在血清高EPO组明显低于低EPO组[(1 150±226)μkat/(L.h)vs(1 740±210)μkat/(L.h),P<0.05)]。多元逐步回归分析显示,血清EPO水平、PCI术后TIMI血流等级和梗死前心绞痛是CK累积释放量的独立预测因子。结论内源性EPO水平高者AMI成功地直接PCI术后梗死面积较少,两者呈负相关。
AIM To study the relation between serum erythropoietin （EPO） levels and the infarct size in patients with acute myocardial infarction （AMI） who had undergone successful primary percutaneous coronary intervention （PCI）. METHODS We studied 86 patients with first ST-segment elevation MI who had received successful primary PCI whthin 12 h from the onset of MI. The serum EPO level and creatine kinase （CK） were measured and the cumulative CK release was calculated. We divided the 86 patients into two groups using the median value（ 19.6 U/L） of the serum EPO levels. A stepwise multiple regression analysis was conducted to assess the possible determinants of cumulative CK release. RESULTS The cumulative CK release of the high EPO group was significantly lower than that of the low EPO group [ （ 1 150±226） μkat/（ L·h） vs （ 1 740 ±210） μkat/（ L·h）, P 〈0. 05 ） ]. The stepwise multiple regression analysis revealed that the absolute serum EPO levels （U/L） , TIMI grads after PCI and preinfarction angina were independent predictors for the cumulative CK release. CONCLUSION The infarct size of the high endogenous EPO level group is significantly smaller than that that of the low EPO level group in patients with AMI subjected to successful primary PCI. There is a negative correlation between the two groups.
出处
《心脏杂志》
CAS
2008年第5期608-609,615,共3页
Chinese Heart Journal
