摘要
目的研究炎性肌病中多发性肌炎/皮肌炎(PM/DM)合并横纹肌溶解综合征(RDM)的临床特征和治疗效果。方法总结北京协和医院1995年2月～2007年2月收治的2例 PM/DM 合并 RDM 患者的临床资料.并复习相关文献。结果 2例均为皮肌炎患者,RDM 出现于疾病活动期,短期内肌肉症状急剧加重,肌酸激酶进行性升高,可伴或不伴有急性肾功能衰竭。结论急性起病、肌肉症状急剧进展的 PM/DM 患者需要鉴别 RDM;而对于反复、持续性 RDM,需除外 PM/DM。治疗上需全面兼顾,及时给予免疫抑制去除肌溶解的诱因,并维护重要脏器功能。重要肌群受累或进展至急性肾功能衰竭提示预后不良。
Objective To study the clinical features and prognosis of polymyositis/dermatomyositis （PM/DM） with rhabdomyolysis （RDM）. Methods The clinical history of 2 cases with DM and RDM in PUMC Hospital from February 1995 to February 2007 were reported, and the related literatures were reviewed. Results Two cases, whose RDM tended to be acute in onset, muscle symptoms became aggravated soon, and creatine kinase level elevated progressively. One case was complicated with acute renal failure. Conclusions Those PM/DM with acute onset and progressively muscle symptoms should be differentiated with RDM, while recurrent or persistent RDM with unknown causes should be differentiated from PM/DM. An overall consideration, especially adequate immunosuppressive therapy and visceral organ protection is necessary. Involvement of cardiac/respiratory muscle or acute renal failure predicts poor prognosis.
出处
《中华临床免疫和变态反应杂志》
2007年第1期63-66,共4页
Chinese Journal of Allergy & Clinical Immunology
