摘要
目的评价小剂量左旋布比卡因复合芬太尼腰麻-硬膜外联合麻醉在剖宫产手术中的麻醉效能、母婴安全和相关不良反应。方法采用随机双盲法,将40例剖宫产手术的足月单胎产妇均分为二组:L组,左旋布比卡因7.5mg加芬太尼20μg与10%葡萄糖水配成2.4ml溶液,20例;B组,布比卡因7.5mg加芬太尼20μg与10%葡萄糖水配成2.4ml溶液,20例。实施腰麻-硬膜外联合麻醉。监测血流动力学变化,评估麻醉效应和维持时间,并观察恶心、呕吐等不良反应及新生儿情况。结果两组感觉阻滞最高平面,到达最高阻滞平面的时间和感觉神经阻滞作用的消退时间比较均无统计学意义;两组血压与心率变化比较无统计学意义;新生儿Apgar评分1min、5min的评分两组比较无统计学意义(P>0.05)。运动神经阻滞起效、持续时间,改良Bromage评分两组比较有统计学意义(P<0.01)。结论与小剂量布比卡因复合芬太尼比较,小剂量左旋布比卡因复合芬太尼腰麻-硬膜外联合麻醉用于剖宫产术同样安全有效。
Objective To evaluate the anaesthesia effect and side-effect of low-dose levobupivacaine plus fentanyl in combined spinal epidural anesthesia undergoing cesarean section. Methods Forthy full-tern gravitas undergoing cesarean section were divided into groups with 20 cases each, Groups L received Levobupivacaine 7.5 mg with 20 μg of fentanyl and 10% glucose liquor to a total amount of 2.4 ml. Groups B received bupivacaine 7.5 mg with 20 μg of fentanyl and 10% glucose liquor to a total amount of 2. 4 ml for spinal anes- thesia. The hemodynamic were monitored. The anaesthesia effect were evaluated. The adverse reaction（ pruritus, nausea,vomitiny,respiratory depression）and Apgar score of neonates at 1 minute and 5 minute were recorded and compared. Results There was no significant difference in the two groups for the common conditions of pregnant women and the apart score of neon ales and tie incidence of adverse reaction. There was no significant difference in the two groups for the onset and duration of sensory block and the peak sensory block plane. The onset and duration of motor block and modifier bromide score （MBS） of motor block were different in the two groups. Conclusion To compare low-dose bupivacaine plus fentanyl, low-dose levobupivacaine plus fentanyl spinal anaesthesia in cesarean section is the same anaesthesia efficiency and safety.
出处
《中国实用医药》
2008年第26期40-41,共2页
China Practical Medicine
关键词
左旋布比卡因
芬太尼
腰麻
剖宫产
Levobupivacaine
Fentanyl
Spinalanaesthesia
Cesarean section
