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肾素-血管紧张素-醛固酮系统与糖尿病微血管并发症的关系 被引量：3

Renin-angiotensin-aldosterone system in the onset and progress of diabetic microvascular complications
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摘要 抑制肾素-血管紧张素-醛固酮系统(RAAS)可以显著降低糖尿病微血管并发症的发生并延缓其进展。糖尿病患者循环内RAAS活性并没有明显增加,因此认为可能是局部RAAS的激活引起的一系列病理生理改变,后者在糖尿病并发症中的作用还需要进一步的研究探讨。 Inhibiting renin-angiotensin-aldosterone system（RAAS） an reduce or delay the onset and progress of microvascular complications of diabetes.The activity of RAAS in circulation was different under diabetes mellitus in many reports.The local RAAS may mediate this pathogenesis.The later exists in many tissues and its activity may be increased in diabetic state.
作者 黄佳佳 汤正义 宁光
机构地区 上海交通大学医学院附属瑞金医院内分泌代谢病科上海市内分泌代谢临床医学中心上海市内分泌代谢病研究所
出处 《国际内科学杂志》 CAS 2008年第9期520-522,526,共4页 International Journal of Internal Medicine
关键词 糖尿病 肾素-血管紧张素-醛固酮系统 微血管并发症 Diabetes mellitus, Renin-angiotensin-aldosterone system（RAAS）, Micro-vascular complication
分类号 R587.1 [医药卫生—内分泌]
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参考文献22

  • 1Atlas SA. The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition. J Manag Care Pharm, 2007,13(8 Suppl B) :9-20.
  • 2Carey RM, Siragy HM. Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation. Endocr Rev,2003,24(3) :261-271.
  • 3Cooper ME. The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications. Am J Hypertens ,2004,17 ( 11 Pt 2 ) : 16S-20S.
  • 4Lavoie JL, Sigmund CD. Minireview: Overview of the Renin-Angiotensin System-An Endocrine and Paracrine System. Endocrinology ,2003,144( 6 ) :2179-2183.
  • 5HOPE Study Investigators. Effects of ramipril on cardiovascular and microvaseular outcomes in people with diabetes mellitus : results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet,2000, 355(9200) :253-259.
  • 6Lindholm LH, Ibsen H, Dahlof B, et al. Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE) : a randomised trial against atenolol. Lancet, 2002,359(9311 ) : 1004-1010.
  • 7Luik PT, Kerstens MN, Hoogenberg K, et al. Low plasma aldosterone despite normal plasma renin activity in uncomplicated type 1 diabetes mellitus: effects of RAAS stimulation. Eur J Clin Invest, 2003, 33(9) :787-793.
  • 8Ravera M, Re M, Weiss U, et al. Emerging therapeutic strategies in diabetic nephropathy. J Nephrol, 2007, 20 ( Suppl 12) :S23-S32.
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二级参考文献5

  • 1Hollenberg NK.Aldosterone in the development and progression of renal injury.Kindney Int,2004,66:1-9.
  • 2Feria I,Pichardo I,Juarez P,et al.Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity.Kidney Int,2003,63:43-52.
  • 3Zhu S,Liu J,Chen L,et al.Chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing Chinese herb in rats.Am J Nephrol,2005,25:23-29.
  • 4Fujisawa G,Okada K,Muto S,et al.Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.Kidney Int,2004,66:1493-502.
  • 5黄凌虹,张国强,叶任高,李幼姬,陈雄辉,关伟明.细胞增殖与凋亡在单侧输尿管梗阻大鼠肾间质纤维化发病中的意义[J].中华肾脏病杂志,2000,16(1):24-27. 被引量：36

共引文献11

同被引文献40

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国际内科学杂志
2008年 第9期

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