摘要
目的总结儿童原发性肾病综合征(primary nephrotic syndrome,PNS)的临床特征。方法回顾性分析1996年8月1日至2006年7月31日964例(其中有747例新发病例)住院PNS患儿的临床及实验室资料。结果747例患儿中,男性568例,女性179例,年龄0.3～17.3岁,中位年龄4.7岁;1～5岁的PNS患儿有385例(51.5%)。与肾炎型肾病相比较,单纯型肾病患儿的血清白蛋白较低(P<0.05),而总胆固醇和低密度脂蛋白较高(P<0.05),两者24h尿蛋白量比较无统计学差异(P>0.05);PNS患儿的血清IgG比正常值低(P<0.01),IgM和IgE比正常值高(P<0.05),IgA和C3与正常值比较无统计学差异(P>0.05)。PNS复发的主要诱因是上呼吸道感染,其次是患儿不规则用药。结论儿童PNS以1～5岁好发,PNS存在体液免疫功能紊乱,降低血脂及预防、控制感染是治疗的关键,而加强宣传、指导对PNS的治疗也至关重要。
Objective To summarize clinical characteristics of primary nephrotic syndrome （PNS） in children. Methods The clinical and laboratory data of 964 children with PNS （ including 747 new cases） were retrospectively analyzed, who were admitted between 1 August, 1996 to 31 July, 2006. Results Of 747 cases, 568 were males and 179 females, with a median age of 4.7 years （0.3 - 17.3）. The total number of children with PNS aged from 1 to 5 years was 385 （51.5%）. Compared with children with nephritic type nephrotic syndrome （NNS）, children with simple type nephrotic syndrome （SNS） had lower albumin （P 〈 0.05 ）, higher cholesterol and lower density lipoprotein （ P 〈 0.05 ）, and no statistical difference in 24-hour urine protein （ P 〉 0.05 ） ; Compared with normal values, children with PNS had lower IgG （P 〈 0.01 ） , higher IgM and IgE （P 〈0.05）, and no statistical difference in C3 and IgA levels （P 〉0.05）. Main motivation of PNS relapse in children was upper respiratory infection, followed by irregular administration of glucocorticoids. Conclusion Children aged from 1 to 5 years are susceptible to PNS. There is humoral immunological dysfunction in PNS children. In the treatment of PNS, to relieve hyperlipidemia and to prevent and control infections is the key point. To strengthen propaganda and guidance about PNS is important as well.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2008年第19期1849-1851,共3页
Journal of Third Military Medical University
关键词
原发性肾病综合征
儿童
临床特征
primary nephrotic syndrome
children
clinical characteristics
