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A anorectal fistula treatment with acellular extracellular matrix: A new technique 被引量:9

A anorectal fistula treatment with acellular extracellular matrix: A new technique
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摘要 AIM: To investigate a new technique of the anorectal fistula treatment with acellular extracellular matrix (AEM). METHODS: Thirty patients with anorectal fistula were treated with AEM. All fistula tracts and primary openings were identified using conventional fistula probe. All tracts were curetted with curet and irrigated with hydrogen peroxide and metronidazole. The AEM was pulled into the fistula tract from secondary to primary opening. The material was secured at the level of the primary opening. The excess AEM was trimmed at skin level at the secondary opening. RESULTS: All of the 30 patients had successful closure of their fistula after a 7-14 d follow-up. The healing rate of anal fistula in treatment group was 100%. The ache time, healing time and anal deformation of treatment group were obviously superior to traditional surgical methods. CONCLUSION: Using AEM anal fistula plug in treatment that causes the anorectal fistula is safe and successful in 100% of patients. It can reduce pain, shorten disease course and protect anal function. AIM: To investigate a new technique of the anorectal fistula treatment with acellular extracellular matrix (AEM). METHODS: Thirty patients with anorectal fistula were treated with AEM. All fistula tracts and primary openings were identified using conventional fistula probe. All tracts were curet-ted with curet and irrigated with hydrogen peroxide and metronidazole. The AEM was pulled into the fistula tract from secondary to primary opening. The material was secured at the level of the primary opening. The excess AEM was trimmed at skin level at the secondary opening. RESULTS: All of the 30 patients had successful closure of their fistula after a 7-14 d follow-up. The healing rate of anal fistula in treatment group was 100%. The ache time, healing time and anal deformation of treatment group were obviously superior to traditional surgical methods. CONCLUSION: Using AEM anal fistula plug in treatment that causes the anorectal fistula is safe and successful in 100% of patients. It can reduce pain, shorten disease course and protect anal function.
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第30期4791-4794,共4页 世界胃肠病学杂志(英文版)
关键词 Acellular extracellular matrix Anorectal fistula 肛门直肠瘘 非细胞外间质 治疗方法 消化道疾病
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参考文献29

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  • 1Johnson E.K.,Gaw J.U.,Armstrong D.N.,廖新华.肛瘘填料与纤维蛋白胶对肛门直肠瘘的闭合效果比较[J].世界核心医学期刊文摘(胃肠病学分册),2006,2(9):20-20. 被引量:12
  • 2C. Neal Ellis M.D.,Stephen Clark M.D.. Fibrin Glue as an Adjunct to Flap Repair of Anal Fistulas: A Randomized, Controlled Study[J] 2006,Diseases of the Colon & Rectum(11):1736~1740
  • 3Lynn O’Connor M.D.,Bradley J. Champagne M.D.,Martha A. Ferguson M.D.,Guy R. Orangio M.D.,Marion E. Schertzer M.D.,David N. Armstrong M.D., F.R.C.S.. Efficacy of Anal Fistula Plug in Closure of Crohn’s Anorectal Fistulas[J] 2006,Diseases of the Colon & Rectum(10):1569~1573
  • 4Andrew A. Shelton M.D.,Mark L. Welton M.D.. Transperineal Repair of Persistent Rectovaginal Fistulas Using an Acellular Cadaveric Dermal Graft (AlloDerm?)[J] 2006,Diseases of the Colon & Rectum(9):1454~1457
  • 5Eric K. Johnson M.D.,Janette U. Gaw M.D.,David N. Armstrong M.D., F.R.C.S.. Efficacy of Anal Fistula Plug vs. Fibrin Glue in Closure of Anorectal Fistulas[J] 2006,Diseases of the Colon & Rectum(3):371~376
  • 6G?ktürk Maralcan,?lyas Ba?konu?,Necdet Aybast?,Avni G?kalp. The Use of Fibrin Glue in the Treatment of Fistula-In-Ano: A Prospective Study[J] 2006,Surgery Today(2):166~170
  • 7Mark H. Whiteford M.D.,John Kilkenny M.D.,Neil Hyman M.D.,W. Donald Buie M.D.,Jeffrey Cohen M.D.,Charles Orsay M.D.,Gary Dunn M.D.,W. Brian Perry M.D.,C. Neal Ellis M.D.,Jan Rakinic M.D.,Sharon Gregorcyk M.D.,Paul Shellito M.D.,Richard Nelson M.D.,Joe J. Tjandra M.D.,Graham Newstead M.D.. Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano (Revised)[J] 2005,Diseases of the Colon & Rectum(7):1337~1342
  • 8Marc Singer M.D.,José Cintron M.D.,Richard Nelson M.D.,Charles Orsay M.D.,Amir Bastawrous M.D.,Russell Pearl M.D.,Julia Sone M.D.,Herand Abcarian M.D.. Treatment of Fistulas-in-Ano With Fibrin Sealant in Combination With Intra-adhesive Antibiotics and/or Surgical Closure of the Internal Fistula Opening[J] 2005,Diseases of the Colon & Rectum(4):799~808
  • 9R. P. Silverman,E. N. Li,L. H. Holton,K. T. Sawan,N. H. Goldberg. Ventral hernia repair using allogenic acellular dermal matrix in a swine model[J] 2004,Hernia(4):336~342
  • 10Gordon N. Buchanan M.Sc., F.R.C.S.,Clive I. Bartram F.R.C.R.,Robin K. S. Phillips M.S., F.R.C.S.,Stuart W. T. Gould M.S., F.R.C.S.,Steve Halligan M.D., F.R.C.R.,Tim A. Rockall M.D., F.R.C.S.,Paul Sibbons Ph.D.,Richard G. Cohen M.D., F.R.C.S.. Efficacy of Fibrin Sealant in the Management of Complex Anal Fistula[J] 2003,Diseases of the Colon & Rectum(9):1167~1174

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