摘要
目的研究肿瘤体外药敏试验中顺铂敏感性的影响因素。方法回顾性分析138例卵巢癌和67例宫颈癌患者的MTT法肿瘤体外药敏试验顺铂敏感性数据,采用非条件logistic回归分析年龄、肿瘤病理类型和顺铂化疗史的间隔时间对体外顺铂敏感性的影响。结果年龄、肿瘤病理类型和顺铂化疗史的间隔时间对体外顺铂敏感性的影响没有统计学意义(P= 0.655 6)。结论卵巢癌和宫颈癌患者体外顺铂敏感性具有较大的个体差异,由于回归系数的误差、样本数小及变量赋值等影响,使本研究得到阴性结果,但有顺铂化疗史的卵巢癌和宫颈癌患者仍然有体外顺铂敏感的可能性。
AIM To study the influence factors on eisplatin inhibiting tumor in vitro. METHODS The eisplatin inhibiting tumor in vitro and related clinical data were collected from 138 cases of ovarian and 67 cases of cervical cancer specimen using chemosensitivity test by the MTT[ 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyherazolium bromide] assay. The effects of age, pathology or time of cisplatin therapy on the cisplatin inhibiting tumor were measured with unconditional logistic regression analysis. RESULTS There was no statistical difference between the influence on cisplatin inhibiting tumor in vitro and age, pathology or time of cisplatin therapy（overall P = 0. 655 6）. CONCLUSION Due to the existing major uariations between eisplatin inhibiting tumor in vitro of ovarian and cervical cancer. The patients receive eisplatin therapy might still have high eisplatin inhibiting tumor in vitro.
出处
《中国临床药学杂志》
CAS
2008年第5期278-279,共2页
Chinese Journal of Clinical Pharmacy
关键词
MTT法
肿瘤
药敏试验
顺铂
MTT assay
tumor
drug sensitive test
cisplatin
