摘要
目的探讨短暂性脑缺血发作(TIA)患者颈动脉狭窄与轻度认知功能障碍的关系。方法采用数字减影血管造影判断颈动脉狭窄程度,用事件相关电位、改良威斯康星卡片分类测试、数字连线测试、数字广度测试等方法评价58例TIA患者的认知功能状况,比较不同程度颈动脉狭窄患者的认知功能状况及轻度认知功能障碍的发病率。结果不同程度颈动脉狭窄的患者,TIA发作次数、认知功能状况、P300潜伏期和波幅、轻度认知功能障碍的发病率差异有统计学意义。随颈动脉狭窄程度增加,认知功能损害加重,轻度认知功能障碍的发病率增加。当狭窄程度超过70%后,总体认知功能损害和轻度认知功能障碍的发病率并不增加。结论颈动脉狭窄与认知功能障碍明显相关,对颈动脉狭窄超过70%的TIA患者,解除颈动脉狭窄可能降低总体认知功能损害,减少轻度认知功能障碍的发生率。
Objective To discuss the relation between carotid stenosis and mild cognitive impairment（MCI）. Methods Fifty eight patients who performed digital substrction angiograpby（DSA）to check carotid stenosis. The cognitive condition were assessed using the event related potential, modifidied verson of Wisconsin card sorting test, trial making test, digist span task, and verb fluecy test. Comparing the carotid stenosis and total cognition and frequency of MCI were performed. Results There were significant differences among the cognitive condition, latency and amplitude of P300, and morbility of MCI. With the increase of carotid stenosis, cognitive impairment aggravated gradually,and the morbility of MCI increased gradually. When the level of carotid stenosis exceeded 70 percent,there were no increases of cognitive impairment and the morbility of MCI. Conclusion The cognitive function decline accompanying carotid stenosis in MCI patients. Treatment of carotid stenosis may decrease cognitive impairment and morbility of MCI on patients with the level of carotid stenosis exceeded 70 percent.
出处
《重庆医学》
CAS
CSCD
2008年第18期2041-2043,共3页
Chongqing medicine
