摘要
目的报道灯盏花素对肝脏缺血-再灌注损伤保护作用的研究进展。方法检索近年来的相关文献,将灯盏花素对肝脏缺血-再灌注损伤的保护作用在实验和临床研究中的情况进行分析和总结。结果灯盏花素的作用广泛,可通过抗氧自由基和抗脂质过氧化,抑制线粒体损伤、细胞内钙超载、细胞凋亡,改善再灌注后微循环和抗凝血等机理保护缺血-再灌注损伤的肝脏。结论灯盏花素对肝脏缺血-再灌注损伤有保护作用,有研究和应用价值。
Objective To report the progression of breviseapine＇s protective effect to hepatic ischemia-reperfusion injury. Methods Pertinent literatures and journal articles published in recent years were reviewed, and the progression of breviscapine protecting hepatic ischemia-reperfusion injury in the experimental and clinical research were analyzed and summarized. Results The role of breviscapine is considerable extensive. It can protect hepatic ischemia reperfusion injury by anti-oxyradical and anti-lipid peroxidation, inhibiting mitochondrial damage, intracellular calcium overload, intra-thromboxane and apoptosis, improving microcirculation, and so on. Conclusion Breviscapine plays a protective role in hepatic ischemia-reperfusion injury, and it will be of great value to application and research.
出处
《中国普外基础与临床杂志》
CAS
2008年第9期708-710,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
灯盏花素
缺血-再灌注
肝损伤
保护
Breviscapine Ischemia-reperfusion Hepatic injury Protection
