摘要
目的:分析 D 二聚体水平在急性主动脉夹层(AAD)早期诊断和预后判断中的作用。方法:回顺分析116例 AAD 患者(AAD 组)和132例同期因胸痛就诊的其它患者(对照组),比较两组间包括 D 二聚体水平在内的各项临床常用指标的差异。结果:D 二聚体>500 μg/L 预测 AAD 的敏感性92.24%,D 二聚体>5 000 μg/L 预测 AAD 的特异性为95.45%。DeBakey Ⅰ型患者 D 二聚体水平显著高于其它临床分型,差异具有统计学意义(P<0.01)。2周内死亡的 AAD 患者 D 二聚体水平显著高于存活的患者,差异具有统计学意义(P<0.05)。结论:D 二聚体的水平与 AAD 夹层撕裂的程度和范围相关,并可能是 AAD 患者不良预后的参考指标。
Objective：To analyse the role of serum D-Dimer in the diagnosis and prognosis of Acute Aortic Dissection（AAD）. Methods： With retrospective analysis, 116 AAD patients were compared with 132 control patients with chest pain in the same period of time to examine the differences of serum D-Dimer and other clinical indexes. Results： D-Dimer had statistical significance in AAD patients and it could be used for AAD prediction from suspected chest pain. If D-Dimer 〉 500 μg/L, the sensitivity of AAD diagnosis was 92.24%. If D-Dimer 〉 5000 μg/L, the specificity was 95.45%. Serum D-Dimer level in DeBakey Ⅰ type AAD was higher than that in other type of AAD （ P 〈 0. 01 ）. Serum D-Dimer in AAD patients died in the first two weeks of onset was significantly higher than those survived patients （ P 〈 0. 05 ）. Conclusions： D-Dimer was an early biomarker in AAD diagnosis and it was correlated with the range and lacerated degree. Higher D-Dimer level might be a non-benign prognosis prediction in AAD.
出处
《中国循环杂志》
CSCD
北大核心
2008年第4期282-285,共4页
Chinese Circulation Journal
