摘要
C-反应蛋白（CRP）是最敏感的急相蛋白指标。越来越多的证据表明，作为脑梗死的主要病因，动脉粥样硬化是一种慢性炎症过程。目前的研究发现，CRP水平及基因多态性与动脉粥样硬化和脑梗死有关。与冠心病相比，超敏CRP与缺血性卒中的关联性更为紧密。文章就CRP的生物学特征、影响CRP水平的因素、CRP水平和基因多态性与脑梗死的相关性的研究进展做了综述。
C-reactive protein （CRP） is the most sensitive indicator of acute phase proteins. A growing body of evidence suggests that atherosclerosis, as a main cause of cerebral infarction, is a chronic inflammatory process, The present studies have found that the CRP levels and genetic polymorphisms are associated with atherosclerosis and cerebral infarction. As compared with coronary artery disease, the association between high-sensitive CRP and ischemic stroke is more closely, This article reviews the advances in research on the biological characteristics of CRP, the factors influencing CRP levels, the CRP levels and the correlation between genetic polymorphisms and cerebral infarction.
出处
《国际脑血管病杂志》
2008年第8期615-619,共5页
International Journal of Cerebrovascular Diseases
关键词
C-反应蛋白
脑梗死
基因多态性
动脉粥样硬化
炎症
C-reactive protein
brain infarction, gene polymorphism
atherosclerosis
inflammation
