摘要
目的调查河北衡水市乙型病毒性肝炎感染情况,为今后乙型病毒性肝炎的防治提供科学依据。方法采用酶联免疫吸附(ELISA)法对15797名医保参保人员进行乙型肝炎5项检测,统计年龄、性别、各阳性模式人数。结果15797例医保参保人员的乙型肝炎5项结果中出现阳性模式13种。其中,表面抗原(HBsAg)总阳性率3.96%(625/15797);核心抗体(抗-HBc)总阳性率13.15%(2078/15797);单表面抗体(抗-HBs)阳性率13.34%(2108/15797)。大、小三阳阳性率年龄分布:20～29岁(1.77%)、30～39岁(3.38%)、40～49岁(3.23%)、50～59岁(4.16%)、60～69岁(1.87%)、≥70岁(1.92%)。抗原阳性模式、抗体阳性模式和疫苗阳性模式在男女之间均显著不同,危险比(RR)分别为:2.25(4.2×10-19),1.96(5.4×10-33)和1.32(8.7×10-11);男女的HBsAg阳性率也显著不同,RR=2.26(P=1.0×10-18)。结论衡水市15797例医保参保人员中慢性乙型肝炎或乙型肝炎携带者占4.06%,既往感染者8.88%,产生免疫力者13.34%;大、小三阳患者在30～59岁为发病高峰期;男性HBsAg阳性率是女性的2.26倍,男性发病率显著高于女性。
Objective To investigate the infection of hepatitis B virus （HBV） in urban population of Hengshui City, Hebei Province, to provide a scientific basis for the prevention and treatment of hepatitis B. Methods The enzyme-linked immunosorbent assay （ELISA） method was used to detect the five serological markers of HBV for 15 797 medicare participants. The distribution of HBV infection in age, gender and various positive modes was summarized. Results Overall, there were 13 positives modes were detected from the results of the 15 797 participants＇ five serological markers of HBV, where, the positive rate of surface antigen （HBsAg） 3.96 % （625/15 797）, of core antibody （anti-HBc） 13.15 % （2 078/15 797）, of single surface antibody （anti-HBs） 13.34% （2 108/15 797）. The rate of HBsAg ＋/HBeAg ＋/HBcAb ＋ or HBsAg ＋/HBcAb ＋/HBeAb ＋ in different age groups： 20-29 yrs 1.77 %, 30-39 yrs 3.38%, 40-49 yrs 3.23%, 50-59yrs 4.16%, 60--69 yrs 1.87%, ≥70 yrs 1.92%. Antigen positive mode, antibody positive mode, vaccines positive mode, and HBsAg ＋ rate were significantly different between men and women, where relative risks （p-value） were 2.25 （4.2 × 10^-19）, 1.96（5.4× 10^-33）, 1.32（8.7× 10^-11） and 2.26（1.0× 10^-18）, respectively. Conclusions Of 15 797 medicare participants, HBV carriers, people with previous infection, and people developed immunity were accounted for 4.06% , 8.88% and 13.34% , respectively. 30-59 yrs was the peak risk period of HBsAg ＋/HBeAg ＋/HBcAb ＋ or HBsAg ＋/HBcAb ＋/HBeAb ＋ . Male HBsAg positive rate is 2.26 times that of women. HBV incidence rate of men was significantly higher than that of women.
出处
《中华疾病控制杂志》
CAS
2008年第4期332-335,共4页
Chinese Journal of Disease Control & Prevention
关键词
保险
长期医疗
肝炎
乙型
多元分析
Insurance, long-term care
Hepatitis B
Multivariate analysis
