2Lan DP. The regulation of p53 function: steiner award lacture. Int J Cancer, 1994,57: 623-627.
3Vogelstein B, Kinzler KW. p53 function and dysfunction. Cell, 1992,70: 523 -526.
4Hollstein M, Sidransky D, Volgelstein B, et al. p53 mutations in hmnan cancers. Science, 1991,253: 49-53.
5Levine AG, Momand J, Finlay CA. The p53 tumor suppressor gene.Nature, 1991, 352:453-456.
6Gao H, Wang LD, Zhon Q, et al.p53 tumor suppressor gene mutation in early esophageal precancerous lesions and carcinoma among high-risk populations in Henan,China. Cancer Res, 1994, 54: 4342-4346.
7Lin J, Chen J, Elenbaas B, et al. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation,binding to mdm-2 and the adenovirus 5EIB 55-kD protein. Genes Dev,1994,8:1235-1246.
8Velculuescu VE,EL-Deiry WS. Biological and clinical importance of the p53 tumor suppressor gene. Clinical Chem, 1996,42:858-868.
9Koshland DE Jr. Molecule of the year. Science, 1993,262:1953.
