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NM23基因/NDPK、CD44v6蛋白表达在非小细胞肺癌中的临床意义 被引量：1

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摘要 肺癌分为非小细胞肺癌（NSCLC）和小细胞肺癌（SCLC）两大类，其中NSCLC约占80%以上。目前肺癌总的5年生存率只有15%左右，90%以上患者死于肺瘤侵袭和转移的相关并发症。侵袭和转移是恶性肿瘤的两个最主要的生物学特征和标志，近年来研究发现了与肿瘤转移呈正负相关的肿瘤转移相关基因和肿瘤转移抑制相关基因，前者的激活和（或）后者的失活能促进或导致肿瘤转移的发生。许多分子生物学标记与肺癌的预后密切相关，可以提示复发和转移的倾向。因此在NSCLC中检测nm23基因/NDPK及CD44v6的表达，对判断预后，预防及治疗NSCLC侵袭和转移将提供有效的途径，形成治疗的生物靶点等方面，均具有重要意义。
作者 帕提古丽.阿尔西丁 张国庆 马玲
机构地区 新疆医科大学附属肿瘤医院
出处 《现代医药卫生》 2008年第20期3057-3059,共3页 Journal of Modern Medicine & Health
关键词 非小细胞肺癌 CD44v6 NM23基因 NDPK 临床意义 蛋白表达 肿瘤转移相关基因 肿瘤转移抑制
分类号 R734.2 [医药卫生—肿瘤] R735.2 [医药卫生—肿瘤]
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  • 1Yan Xin,Xiao Ling Li,Yan Ping Wang,Su Min Zhang,Hua Chuan Zheng,Dong Ying Wu,Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China.Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas[J].World Journal of Gastroenterology,2001,7(1):53-59. 被引量：39
  • 2Jun Hui Cui~1 Uwe Krueger~2 Doris Henne-Bruns~2 Bemd Kremer~2 Holger Kalthoff~2 ~1Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China ~2Department of General Surgery,Christian-Albrechts-University,Kiel,GermanyDr.Jun Hui Cui graduated from Zhejiang Medical University in 1984,earned master degree in 1990,studied in the Surgical Department of Kiel University and worked in the Lab of Molecular Oncology of Kiel University from 1994-1997achieved M.D.from Kiel University.Germany,now associate professor of surgery,specialized in colorectal oncology.Adviser of graduated student for master degree,having 20 publications published in key Chinese or English journals..Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases[J].World Journal of Gastroenterology,2001,7(3):381-386. 被引量：19
  • 3蔡郑东,李国东.肿瘤转移机制研究新热点——ezrin蛋白[J].中华肿瘤杂志,2005,27(6):322-325. 被引量：18
  • 4雷文东,张汝刚,闫水忠,王秀琴,牟巨伟,张大为,吴旻.nm23基因在人肺癌中的表达及其与肺癌淋巴结转移的关系[J].中华肿瘤杂志,1994,16(4):277-279. 被引量：58
  • 5Korrapati V, Gaffney M, Larsson LG, et al. Effect of HER2/neu expression on survival in non-small cell lung cancer[J]. Clin Lung Cancer, 2001,2(3):216-219.
  • 6Katakura H,Tanaka F,Oyanagi H,et al.Clinical significance of nm23 expression in resected pathologic-stage Ⅰ,non-small cell lung cancer[J].Ann Thorac Surg.2002;73(4):1060-1064.
  • 7Tomita M,Ayabe T,Matsuzaki Y,et al.Expression of nm23-H1 gene product in mediastinal lymph nodes from lung cancer patients[J].Eur J Cardiothorac Surg.2001;19(6):904-7.
  • 8傅西林 见:刘复生 刘彤华 主编.乳腺恶性肿瘤[A].见:刘复生，刘彤华，主编.肿瘤病理学[C].北京,北京医科大学、中国协和医科大学联合出版社,1997.164.
  • 9STEEG P S,BEVILACQUA G,KOOPER L,et al.Evidence for a novel gene associated with low tumor metastatic potential[J].J Natl Cancer Inst,1988,80(3):200 204.
  • 10LAOCMBE M L,MILON L,MUNIER A,et al.The human Nm23/nucleoside diphosphate kinases[J].J Bioenerg Biomembr,2000,32(3):247-258.

共引文献60

同被引文献13

  • 1Harris N,Taylor J E,Roberts J A,et al.Isolation of amRNA encoding a nucleoside diphosphate kinase fromtomato that is up-regulated by wounding[J].Plant MolBiol,1994,25:739-742.
  • 2Escobar M L,Marttila S,Hɑaknsson G,et al.Heatstress response in pea involves interaction of mitochon-drial nucleoside diphosphate kinase with a novel 86-kilodalton protein[J].Plant Physiol,2001,126:69-77.
  • 3Moon H,Lee B,Choi G,et al.NDPkinase 2interactswith two oxidative stress-activated MAPKs to regulatecellular redox state and enhances multiple stress toler-ance in transgenic plants[J].Proc Natl Acad Sci,2003,100:358-63.
  • 4Ryu J S,Kim J I,Kunkel T,et al.Phytochrome-specifictype 5phosphatase controls light signal flux by enhan-cing phytochrome stability and affinity for a signaltransducer[J].Cell,2005,120:395-406.
  • 5Zimmermann S,Baumann A,Jaekel K,et al.UV-responsive genes of Arabidopsis revealed by similarityto the Gcn4-mediated UV response in yeast[J].J BiolChem,1999,274:17017-17024.
  • 6Novikova G V,Moshkov I E,Smith A R,et al.Theeffect of ethylene and cytokinin on guanosine 50-triphosphate binding and protein phosphorylation inleaves of Arabidopsis thaliana[J].Planta,1999,208:239-246.
  • 7Escobar M L,Marttila S,Hakansson G,et al.Heatstress response in pea involves interaction of mitochon-drial nucleoside diphosphate kinase with a novel 86-kilodalton protein[J].Plant Physiol,2001,126:69-77.
  • 8Hasunuma K,Yabe N,Yoshida Y,et al.Putative func-tions of nucleoside diphosphate kinase in plants andfungi[J].J Bioener Biomem,2003,35:57-65.
  • 9Yano A,Shimazaki T,Kato A,et al.Molecular cloningand nucleotide sequence cDNA encoding nucleosidediphosphate kinase of rice(Oryza sativa L.)[J].PlantMol Biol,1993,23:1087-1090.
  • 10Choi G,Yi H,Lee J.Phytochrome signaling is media-ted through nucleoside diphosphate kinase2[J].Na-ture,1999,401:610-613.

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现代医药卫生
2008年 第20期

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