摘要
目的:了解新疆地区汉族慢性乙型肝炎病毒(HBV)感染者基因型情况与临床的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法,分析新疆汉族慢性HBV感染者基因型。同时检测HBeAg、肝功、血常规。结果:新疆汉族217例慢性HBV感染者,其中慢性乙型肝炎148例,乙肝肝硬化48例,肝癌21例。B基因型占13.8%(30/217),C基因型占74.5%(162/217),C/D重组体占9.2%(20/217),D基因型占2.3%(5/217)。4种基因型中,C基因型的年龄明显高于B基因型和C/D重组体,C基因型在HBeAg、CH、LC、HCC所在比例明显高于B基因型、C/D重组体、D基因型,均有统计学意义(P<0.05)。4种基因型在性别(χ2=6.580,P=0.317)、ALT(F=0.646,P=0.779)、AST(F=0.173,P=0.792)、TBIL(F=1.194,P=0.507)、ALB(F=1.390,P=0.477)等方面比较,无统计学意义。结论:新疆地区汉族慢性乙型肝炎以C基因型为主,慢性乙型肝炎C基因型病情重,预后差。
Objective ：To understand the relationship between HBV genotype and chnical characteristic in Han people with chronic HBV infection in Xinjiang area.Methods：The HBV genotype in Han people with chronic HBV infection was anaysed by PCR-restrietion fragment length polymorphism （PCR-RFLP）.The blood routine examination,HBeAg and liver function were respectively detected at the same time.Results：Of 217 patients with chomic HBV infection, 148 were chronic hepatitis B （CH）,48 hepatitie cirrhosis （LC） and 21 hepatocareinoma （HCC）.The genotype B accounted for 13.8% ,genotype C 74.5% ,recombinant （C/D） 9.2% and genotype D 2.3%.In the 4 HBV genotypes,the age in genotype C was significantly higher than that in genotypes B and C/D （P〈0.05）;the ratioes of HBeAg,CH, LC and HCC in genotype C were significantly higher than those in genotypes B ,C/D and D （P〈0.05）,but without statistical difference in sex （Х^2=6.580,P=0.317）,ALT（F=0.646,P=-0.779） ,AST（F=0.173 ,P=0.792）,TBIL（F=1.194,P=0.507） and ALB（F=1.390,P=0.477） among them. Conclusion：The genotype C is main genotype in Han people with chronic HBV infection in Xinjiang area,and can lead to the exacerbation,with poor prognisis.
出处
《现代医药卫生》
2008年第19期2878-2880,共3页
Journal of Modern Medicine & Health
关键词
乙型
肝炎病毒
基因型
Hepatitis B
Hepatitis virus
Genotype
