摘要
目的:观察单纯2型糖尿病(T2DM)和糖尿病肾病(DN)患者血清C-反应蛋白(CRP)的变化,探讨其在糖尿病及DN发生发展中的影响。方法:将98例住院患者及门诊健康体检者分为正常对照30例,T2DM组68例,其中单纯糖尿病组36例,DN组32例,用酶联免疫吸附法测定血浆CRP,并与正常对照组比较。结果:正常对照组CRP低于T2DM组,单纯T2DM组低于DN组。组间比较差异有显著性意义(P<0.05),单因素相关分析显示,CRP与空腹血糖、低密度脂蛋白、体重指数呈正相关,与高密度脂蛋白呈负相关。与年龄、TC、血压、HOMA-IR等无关。结论:CRP与T2DM和DN的发生发展相关,CRP可作为早期诊断、治疗T2DM和DN及预测其预后的参考指标。
Objective：To observe the pIasma concentration of C-reactive protein （CRP） in type 2 diabetes mellitus （T2DM） with/ without diabetic nephroprathies （DN）, and explore the influences of CRP in the genesis and development of them. Methods：We selected 98 patients in our hospital and divided them into 2 groups： normal control group and T2DM group,including simple T2DM and diabetic nephroprathies.in addition,we measured the plasma CRP with ELISA.Results：The plasma CRP concentration in the control group was lower than that in T2DM group, and the level in simple T2DM patients was lower than that in the diabetic nephropathy patients,with an obviously decreased tendency,and the significant difference was found in the plasma CRP concentration among groups （P〈0.05）. The correlation analysis showed that the plasma CRP concentration was positively correlated with FPG,LDL-C,BMI,negatively correlated with HDL-C,but not correlated with age,TC,BP and HOMA-IR.Conclusion：There may be relation between plasma concentrations of CRP and the occurrence of T2DM and DN. CRP can be taken as the index for the early diagnosis.treatment and prediction of prognosis in the patients with T2DM and DN.
出处
《现代医药卫生》
2008年第19期2874-2876,共3页
Journal of Modern Medicine & Health
