摘要
目的探讨蜂花前清茶对前列腺炎大鼠的影响及其可能机制。方法通过对大鼠前列腺内注射金黄色葡萄球菌和角叉菜胶的方法,分别建立大鼠感染性和非感染性前列腺炎模型,以血清前列腺酸性磷酸酶活性、前列腺液中白细胞总数、卵磷脂小体密度以及前列腺组织中Zn含量的变化为指标,观察蜂花前清茶对两种病理模型的影响。TBARS法测定血清及前列腺组织匀浆中丙二醛(MDA)的含量,ORAC法测定抗氧化能力指数。结果蜂花前清茶可显著提高前列腺液中Zn含量和卵磷脂小体密度,降低白细胞总数,有效抑制血清酸性磷酸酶和MDA含量的升高,并能提高前列腺组织的抗氧化能力指数。结论蜂花前清茶对前列腺炎的抑制作用可能与其改善血清前列腺酸性磷酸酶活性、Zn含量及前列腺组织的氧化应激状态相关。
Objective To investigate the inhibitory effect of Fenghua Qianqing Medicinal Tea （FQMT） on experimental pro- statitis in rats and to explore its therapeutic mechanism. Methods Staphyloccocus aureus rosenbach and carrageenan were in- jected into rats respectively to establish the bacterial prostatitis and nonbacterial prostatitis. Then the rats were administrated o- rally with FQMT at different dosages. After treatment, the rats were sacrificed and the prostatic and serum acid phosphatase level and MDA content, the value of Zn content in prostatic tissue, the numbers of white blood cell and the density of lecithin corpuscle in prostatic fluid, as well as oxygen radical absorbance capacity （ORAC） values in prostate were measured. Results The value of Zn content, the density of lecithin corpuscle as well as ORAC raised significantly, and the numbers of WBC and MDA decreased in prostatic fluid of rats with prostatitis after treatment with FQMT. Conclusion The inhibitory mechanism of FQMT on chronic prostatitis in Rats may be related to improvement of the prostatic acid phosphatase level, the content of Zn and oxidative status.
出处
《中药新药与临床药理》
CAS
CSCD
2008年第5期343-346,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
蜂花前清茶
前列腺炎
氧化应激
ZN
酸性磷酸酶
Fenghua Qianqing Medicinal Tea
Prostatitis
Oxidative stress
Zn
Acid Phosphatase
