摘要
概述了中国科学技术大学神经毒理学实验室在铅对神经系统学习记忆功能的损伤及药物的修复机制方面的研究进展,主要包括:①铅对海马突触可塑性的影响;②铅影响离子通道的作用机制;③铅对NMDA受体、非NMDA受体及其通道特性的损伤;④铅与神经递质的相互作用;⑤铅影响基因对学习记忆的调控;⑥牛磺酸,神经节苷脂,抗氧化剂等药物对铅引起的学习记忆损伤的修复机制.
The advances made in lead-induced impairment of learning and memory in the nervous system and mechanisms of pharmacals repair in Neurotoxicolog Lab in University of Science and Technology of China were described. They include：①the effect of lead on synaptic plasticity in hippocampus; ②the mechanism of effect of lead on ion channels; ③lead-induced impairment of NMDA receptor, non NMDA receptors and receptor channels; ④the interaction between lead and neurotransmitters; ⑤the effect of lead on gene regulation; ⑥the repair mechanism of pharmacals （Taurine, Ganglioside, antioxidants, etc. ） on lead-induced impairment.
基金
国家重点基础研究发展(973)计划(2002CB512907)
国家自然科学基金重点项目(39630270
30630057)
国家自然科学基金(30170809
3000039
30300288)
中国科学院知识创新工程(KZCX2-410
ZCX3-SW-437)
教育部博士学科点专项科研基金(1999035811
20020358053)
中国科学技术大学基金(KB0811)资助
关键词
铅
学习记忆
突触可塑性
通道和受体
药物
修复机制
lead
learning and memory
synaptic plasticity
channels and receptors
pharmacals
repair mechanism
