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抑郁症患者的定量感觉研究

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摘要 目的研究抑郁症患者定量感觉检查(QST)温度觉阈值的特点以及抗抑郁治疗后对QST的影响。方法选择有主观感觉障碍的31例抑郁症患者和30名正常对照组的感觉阈值,分别用包括反应时间在内的Limits法和不包括反应时间在内Levels法测定四肢的冷觉(CS)、温觉(WS)、热痛觉(HP)、冷痛觉(CP)阈值,并进行比较分析。抑郁症组抗抑郁治疗8周后复查QST,治疗前后比较QST阈值结果。结果两种方法所测CS、WS、HP、CP阈值,正常人四肢差异无统计学意义(P>0.05);抑郁症组用Limits法所测定的感觉阈值明显较Levels法的阈值增高。两组比较:抑郁症组Limits法所测阈值较对照组增高(P<0.05);而Levels法显示两组的阈值接近于正常对照组(P>0.05)。抗抑郁治疗后,抑郁症组Limits法增高的阈值明显下降(P<0.05)。结论抑郁症患者存在QST的异常,抑郁症的感觉障碍可能与中枢反应时间延长有关。
出处 《中国实用医药》 2008年第25期47-49,共3页 China Practical Medicine
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