摘要
目的探讨原发性高血压（ＥＨ）患者红细胞免疫状态及其与循环免疫复合物（ＣＩＣ）的关系。方法用酵母菌法和光电比色法检测１０２例ＥＨ患者红细胞免疫粘附能力、红细胞免疫粘附调节因子及ＣＩＣ。结果ⅡⅢ期ＥＨ患者红细胞Ｃ３ｂ受体花环率（ＲＢＣ—Ｃ３ｂＲＲ）低于正常人，且ⅠⅡⅢ期呈进行性降低。红细胞免疫复合物花环率（ＲＢＣ—ＩＣＲ）与正常人无显著性差异，红细胞免疫粘附促进因子活性低于正常组，且与ＲＢＣ—Ｃ３ｂＲＲ有正相关关系，红细胞免疫粘附抑制因子变化不显著，Ⅰ期ＥＨ患者ＣＩＣ正常，而ⅡⅢ期ＥＨ患者ＣＩＣ的阳性率显著高于正常人。结论ＥＨ患者存在继发性的红细胞免疫粘附能力下降和ＣＩＣ升高，此改变可能与红细胞膜上的Ｃ３受体数目减少和继发性的血管壁组织损伤有关。
Objective To study red-cell immune state and circulation immune complex (CIC) in patiemts with essential hypertention (EH). Methods The red-cell immune adherence (RCIA), red-cell immune absorption regulatory factor (RCIARF) and CIC were detected with Guel's method and colorimetric analysis in 102 patients with EH. Results The rosette rate of red blood cell C3b receptor (RBC-C3bRR), which was progressively in patients with EH stage Ⅰ, stagy Ⅱ and stagy Ⅲ, was lower than that in normal group. There was no significant difference in normal group. There was no significant difference in rosette rate of RBC immune cemplex(RBC-ICR) between normal group and patients with EH. The activity of RCIARF was lower than that in normal group. There was a positive correlation between RCIARF and RBC-C3bRR. There was no remarkable change in inhibitory factor. CIC was normal in patients with EH stage I while positive rate of CIC in patients with EH stage Ⅱ and stage Ⅲ was remarkably higher than that in normal group. Conclusion In patients with EH, the RCIA decreases and CIC increases, which may be related to the reduce of C3 receptor type I on the erythrocyte and the secondary demages to vascular tissure.
出处
《泰山医学院学报》
1997年第4期278-282,共5页
Journal of Taishan Medical College
关键词
高血压
红细胞
免疫粘附能力
循环免疫复合物
essential hypertention
red-cell immune adherence
circulation immune complex
