摘要
用高脂饲料喂养雄性ＳＤ大鼠５周，观察硒、锌与葛根、山楂、决明子联用对高脂血症和脂肪肝的预防作用。结果显示，上述成分联合应用可明显抑制血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－ｃ）、甘油三酯（ＴＧ）、动脉粥样硬化指数（ＡＩ）的增高和升高高密度脂蛋白胆固醇（ＨＤＬ－ｃ）、抗动脉粥样硬化指数（ＡＡＩ）以及阻止肝脏脂肪变性。另外，对高脂血症和脂肪肝大鼠，联合应用硒、锌与葛根、山楂和决明子５周，结果显示，用药大鼠ＴＣ、ＬＤＬ－ｃ、ＴＧ、ＡＩ显著降低，ＨＤＬ－ｃ、ＡＡＩ显著升高，脂肪肝的恢复明显加快。提示，硒、锌与葛根、山楂、决明子联合应用，对高脂血症和脂肪肝有良好的防治作用。
To observe the combined prophylactic effects of Selenium, Zinc, Radix Puerariae, Fructus Crataegi and Semen Cassiae on blood lipid and fatty liver, the Sprague-Dawley rats fed with high-fat diet for 5 weeks were treated with the above ingredients. The results showed that TC,LDL-c,TG and AI (atherogenic index) in the treated group were markedly inhibited, HDL-c and AAI (anti-atherogenic index) elevated and fatty degeneration of liver stopped. The rats with hyperlipemia and fatty liver were also treated with the above ingredients for 5 weeks. The results showed that after treatment, TC,LDL-c, TG, AI were significantly lowered, but HDL-c, AAI elevated and the recovery of fatty liver more rapid. The combined use of Se, Zn, Radix Puerariae, Fructus Crataegi and Semen Cassiae is very effective in prevention and treatment of hyperlipemia and fatty liver.
出处
《解放军预防医学杂志》
CAS
北大核心
1997年第6期411-414,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
硒
锌
葛根
山楂
决明子
高脂血症
脂肪肝
Selenium, Zinc, Radix Puerariae, Fructus Crataegi, Semen Cassiae, blood lipid, fatty liver
