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全血γ干扰素测定试验在结核病诊断中的应用 被引量：6

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摘要 实验室检验是结核病最重要的诊断方法。目前结核病诊断的金标准是临床检查结合细菌培养和痰涂片镜检。但是结核分枝杆菌（MTB）培养周期长且阳性率低，对于这些患者的诊断只能借助于临床观察和X线检查。因此，上述手段在需要早期发现和及时治疗的潜伏性和活动性结核病患者的快速诊断中受到限制。近年来免疫学检测以其简便、快速以及较高的特异度和敏感度，在结核病的诊断中得到了广泛的应用。
作者 孙琳 申阿东
机构地区 首都医科大学附属北京儿童医院儿科研究所
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2008年第9期1070-1072,共3页 Chinese Journal of Laboratory Medicine
基金 国家自然科学基金资助项目（30471841）
关键词 结核病诊断 测定试验 Γ干扰素 全血 结核分枝杆菌 实验室检验 痰涂片镜检 结核病患者
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献15

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  • 2Renshaw PS, Panagiotidou P, Whelan A, et al. Conclusive evidence that the major T-cell antigens of the Mycobactefium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1 : 1 complex and characterization of the structural properties of ESAT- 6, CFP-10, and ESAT-6 and CFP-10 complex. J Biol Chem, 2002,277 : 21598 -21603.
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同被引文献44

  • 1史清明,倪进发,陶芳标.某市高等院校大学生结核病患病情况调查[J].中国学校卫生,2004,25(5):541-542. 被引量：26
  • 2王陇德.中国结核病控制现状及展望[J].中华结核和呼吸杂志,2006,29(8):505-506. 被引量：120
  • 3Mazurek GH, Jereb J, Lobue P, Iademareo MF, Metchoek B, Vernon A. Guidelines for using the QuantiFERON-TB-Glod test for detecting Mycobacterium tuberculosis infection, United States[J].MMWR Recomm Rep, 2005,54(RR-15):49-55.
  • 4Tsiouris SJ, Coetzee D, Toro PL, Austin J, Stein Z, E1-Sadr W. Sensitivity analysis and potential uses of novel gamma inter- feron release assay for diagnosis of tuberculosis[J]. J Clin Microbiol, 2006,44(8): 2844--2850.
  • 5Arend SM, Thijsen BF, Leyten EM, Bouwman JJ, Franken WP, Koster BF, Cobelens FG, van Houte A J, Boss'ink AW. Comparison of two interferon-γ assays and tuberculin skin test for tracing tuberculosis contacts[J]. Am J Respir Crit Care Med, 2007, 175 (6): 618--627.
  • 6Lalvani A. Diagnosing tuberculosis infection in the 21st century. new tools to tackle an old enemy[J]. Chest, 2007,131 (6) : 1898-1906.
  • 7Nishimura T, Hasegawa N, Mori M, Takebayashi T, Harada N, Higuchi K, Tasaka S, Ishizaka A. Accuracy of an interferongamma release assay to detect active pulmonary and extra-pulmonary tuberculosis[J]. Int J Tuberc Lung Dis, 2008,12 (3) : 269-274.
  • 8Ravn P, Munk ME, Andersen AB, Lundgren B, Lundgren JD, Nielsen LN, Kok-Jensen A, Andersen P, Weldingh K. Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis[J]. Clin Diagn Lab Immunol, 2005, 12(4) :491-496.
  • 9Tsiouris SJ, Austin J, Toro P, Coetzee D, Weyer K, Stein Z, EI-Sadr WM. Results of a tuberculosisspecific IFN-gamma assay in children at high risk for tuberculosis infection[J]. Int J Tuberc Lung Dis,2006,10 (8) :939-941.
  • 10Fathy MM, Asaad A, Mansour M, El-Said H, El-Haddad OK. Cellular interferon-gamma based assay for diagnosis of pulmonary tuberculosis[J]. Egypt J Immunol, 2007,14 (1) : 33-41.

引证文献6

二级引证文献57

中华检验医学杂志
2008年 第9期

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